Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence: Results from a UK Birth Cohort.

Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence: Results from a UK Birth Cohort.
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DOI:
10.1177/10870547211036755
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发表时间:
2022-04
影响因子:
3
通讯作者:
Francesconi M
Francesconi M
中科院分区:
医学2区
文献类型:
--
作者:
Ji D;Flouri E;Papachristou E;Francesconi M

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注意力缺陷多动障碍(ADHD)儿童表现出下丘脑-垂体-肾上腺(HPA)轴的功能减退。多动/注意力不集中症状与HPA轴功能障碍之间的关联是否在一般儿童人群中也存在尚不清楚。我们评估了英国普通人群队列中4至13岁多动/注意力不集中症状的纵向轨迹与15岁基础皮质醇谱之间的相关性。自童年以来持续高水平的多动/注意力不集中症状的青少年表现出较低的早晨皮质醇总量和较小的昼夜下降,即使在调整混杂因素后。没有发现任何症状轨迹和皮质醇觉醒反应,昼夜斜率或每日皮质醇输出之间的关联。这项研究提供了证据,在青少年慢性多动症/注意力不集中症状的一般人群中皮质醇减少。
Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear. We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort. Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol. This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population.
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