Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients
Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients
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MET基因拷贝数增加对食管鳞状细胞癌患者的生存产生负面影响
DOI：
10.1186/s12885-019-5450-6
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发表时间：
2019-03
期刊：
影响因子：
3.8
通讯作者：
Song Q
中科院分区：
文献类型：
--
作者：
Wang Y;Jiang Z;Xu C;Wang H;Tan L;Su J;Wang X;Jiang D;Hou Y;Song Q
背景：由于间充质上皮转化（MET）扩增已被视为潜在的治疗靶点，因此了解其患病率和预后重要性至关重要。然而，其在食管鳞状细胞癌（ESCC）中的临床病理特征尚不清楚。方法：我们利用组织芯片通过荧光原位杂交（FISH）检测495例食管鳞状细胞癌患者的MET基因状态。评估预后意义以及与各种临床病理参数的相关性。结果：495例患者中，28例（5.7%）MET FISH阳性，其中5例（1%）具有真正的基因扩增。 MET FISH 阳性与临床病理特征之间没有统计学上显着的关联。 28 名 MET FISH 阳性患者的预后明显较差（无病生存期/DFS，P < 0.001 和总生存期/OS，P = 0.001）。多变量分析显示，MET FISH 阳性是 DFS（风险比/HR，1.953；95% 置信区间/CI，1.271-2.999；P = 0.002）和 OS（HR，1.926；95% CI，1.243-2.983；P = 0.003）的独立预后因素。在 I-II 期 ESCC 和 III-IVa 期 ESCC 中，MET FISH 阳性与 DFS（P = 0.022 和 0.020）和 OS（P = 0.046 和 0.024）相关。 MET FISH 阳性的 I-II 期 ESCC 和 FISH 阴性的 III-IVa 期 ESCC 之间没有检测到统计学显着性（DFS，P = 0.492 和 OS，P = 0.344）。结论：MET 基因拷贝数增加是 ESCC 的一个独立预后因素，ESCC 可能因 MET 基因拷贝数增加而上期。结果表明，在临床治疗和随访计划中，增加的 MET 基因拷贝数是一个非常有前途的参数。
Backgrounds:Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal squamous cell carcinoma (ESCC).Methods:We investigated MET gene status with fluorescence in situ hybridization (FISH) assay in 495 ESCC cases using tissue microarrays. Prognostic significance as well as correlations with various clinicopathological parameters was evaluated.Results:Among 495 patients, 28 (5.7%) cases were MET FISH positive, including 5 cases (1%) with true gene amplification. There were no statistically significant associations between MET FISH-positivity and clinicopathologic characteristics. A significantly poorer prognosis was observed in 28 patients with MET FISH-positivity (disease free survival/DFS, P < 0.001 and overall survival/OS, P = 0.001). Multivariate analysis revealed MET FISH-positivity was an independent prognostic factor for DFS (hazard ratio/HR, 1.953; 95% confidence interval/CI, 1.271-2.999; P = 0.002) and OS (HR, 1.926; 95% CI, 1.243-2.983; P = 0.003). MET FISH-positivity was associated with DFS (P = 0.022 and 0.020) and OS (P = 0.046 and 0.024) both in stage I-II ESCC and in stage III-IVa ESCC. No statistical significance (DFS, P = 0.492 and OS, P = 0.344) was detected between stage I-II ESCC with MET FISH-positivity and stage III-IVa ESCC with FISH-negativity.Conclusions:Increased MET gene copy number is an independent prognostic factor in ESCC, and ESCC might have potentially been up-staged by increased MET gene copy number. The results indicate that increased MET gene copy number is a very promising parameter, in clinical therapy and follow-up plans.
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影响因子：
--
作者：
Kawakami H;Okamoto I;Arao T;Okamoto W;Matsumoto K;Taniguchi H;Kuwata K;Yamaguchi H;Nishio K;Nakagawa K;Yamada Y
通讯作者：
Yamada Y
影响因子：
64.8
作者：
Cancer Genome Atlas Research Network;Analysis Working Group: Asan University;BC Cancer Agency;Brigham and Women’s Hospital;Broad Institute;Brown University;Case Western Reserve University;Dana-Farber Cancer Institute;Duke University;Greater Poland Cancer Centre;Harvard Medical School;Institute for Systems Biology;KU Leuven;Mayo Clinic;Memorial Sloan Kettering Cancer Center;National Cancer Institute;Nationwide Children’s Hospital;Stanford University;University of Alabama;University of Michigan;University of North Carolina;University of Pittsburgh;University of Rochester;University of Southern California;University of Texas MD Anderson Cancer Center;University of Washington;Van Andel Research Institute;Vanderbilt University;Washington University;Genome Sequencing Center: Broad Institute;Washington University in St. Louis;Genome Characterization Centers: BC Cancer Agency;Broad Institute;Harvard Medical School;Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University;University of North Carolina;University of Southern California Epigenome Center;University of Texas MD Anderson Cancer Center;Van Andel Research Institute;Genome Data Analysis Centers: Broad Institute;Brown University:;Harvard Medical School;Institute for Systems Biology;Memorial Sloan Kettering Cancer Center;University of California Santa Cruz;University of Texas MD Anderson Cancer Center;Biospecimen Core Resource: International Genomics Consortium;Research Institute at Nationwide Children’s Hospital;Tissue Source Sites: Analytic Biologic Services;Asan Medical Center;Asterand Bioscience;Barretos Cancer Hospital;BioreclamationIVT;Botkin Municipal Clinic;Chonnam National University Medical School;Christiana Care Health System;Cureline;Duke University;Emory University;Erasmus University;Indiana University School of Medicine;Institute of Oncology of Moldova;International Genomics Consortium;Invidumed;Israelitisches Krankenhaus Hamburg;Keimyung University School of Medicine;Memorial Sloan Kettering Cancer Center;National Cancer Center Goyang;Ontario Tumour Bank;Peter MacCallum Cancer Centre;Pusan National University Medical School;Ribeirão Preto Medical School;St. Joseph’s Hospital &Medical Center;St. Petersburg Academic University;Tayside Tissue Bank;University of Dundee;University of Kansas Medical Center;University of Michigan;University of North Carolina at Chapel Hill;University of Pittsburgh School of Medicine;University of Texas MD Anderson Cancer Center;Disease Working Group: Duke University;Memorial Sloan Kettering Cancer Center;National Cancer Institute;University of Texas MD Anderson Cancer Center;Yonsei University College of Medicine;Data Coordination Center: CSRA Inc.;Project Team: National Institutes of Health
通讯作者：
Project Team: National Institutes of Health
MET蛋白过表达和基因扩增在局部晚期鼻咽癌中的预后价值
影响因子：
--
作者：
Li Y;Li W;He Q;Xu Y;Ren X;Tang X;Wen X;Yang X;Sun Y;Zeng J;Yun J;Liu N;Ma J
通讯作者：
Ma J
影响因子：
2.6
作者：
Philippe B;Myriam O;Jean-Jacques M;Benoît P
通讯作者：
Benoît P
食管鳞状细胞癌的流行病学
DOI：
10.1007/978-981-15-4190-2_1
发表时间：
2020
期刊：
Esophageal Squamous Cell Carcinoma
影响因子：
--
作者：
T. Yamaji;S. Tsugane
通讯作者：
S. Tsugane