Fortification of foods with folic acid--how much is enough?

Fortification of foods with folic acid--how much is enough?
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叶酸强化食品——多少才足够?

DOI:
10.1056/nejm200005113421911
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发表时间:
2000
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Mills,JL
Mills,JL
中科院分区:
--
文献类型:
--
作者:
Mills,JL

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在20世纪90年代早期,两项随机临床试验表明,叶酸或含有叶酸的多种维生素可以大大降低妇女生育神经管缺陷儿童的风险,前提是在怀孕前服用维生素。21992年,公共卫生局建议所有有能力怀孕的育龄妇女摄入400微克叶酸。毫不奇怪,在一个每年有一半的怀孕妇女不打算怀孕的国家,对这项建议的遵守情况很差。
In the early 1990s two randomized clinical trials showed that folic acid, or multivitamins containing folic acid, could substantially reduce a woman's risk of bearing a child with a neural-tube defect, provided that the vitamins were taken before conception.1,2In 1992 the Public Health Service recommended that all women of childbearing age who are capable of becoming pregnant consume 400 μg of folic acid daily.3Not surprisingly, in a country where half the women who become pregnant each year are not planning to do so, compliance with this recommendation has been poor.4At the time the recommendation was made, we . . .
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DOI: --
发表时间: 1999
期刊: Seminars in hematology.
影响因子: --
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通讯作者: Rothenberg,SP