Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.
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DOI：
10.1084/jem.20052494
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发表时间：
2006-05-15
期刊：
影响因子：
--
通讯作者：
Neefjes JJ
中科院分区：
文献类型：
--
作者：
Reits EA;Hodge JW;Herberts CA;Groothuis TA;Chakraborty M;Wansley EK;Camphausen K;Luiten RM;de Ru AH;Neijssen J;Griekspoor A;Mesman E;Verreck FA;Spits H;Schlom J;van Veelen P;Neefjes JJ
放射疗法是最成功的癌症疗法之一。这里研究了辐射对 MHC I 类分子抗原呈递的影响。由于三种反应的结果，MHC I 类分子的细胞表面表达以辐射剂量依赖性方式连续多天增加。最初，现有蛋白质的降解增强，导致细胞内肽库增加。随后，由于雷帕霉素途径的哺乳动物靶标的激活而增强的翻译导致肽产生、抗原呈递以及受辐射细胞的细胞毒性T淋巴细胞识别增加。此外，γ-辐射产生了新的蛋白质，导致 MHC I 类分子呈递新的肽，并被细胞毒性 T 细胞识别。我们证明，只有在肿瘤组织放疗之前，免疫疗法才能成功根除小鼠结肠腺癌。我们的研究结果表明定向放射治疗可以提高肿瘤免疫治疗的疗效。
Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on antigen presentation by MHC class I molecules was studied. Cell surface expression of MHC class I molecules was increased for many days in a radiation dose-dependent manner as a consequence of three responses. Initially, enhanced degradation of existing proteins occurred which resulted in an increased intracellular peptide pool. Subsequently, enhanced translation due to activation of the mammalian target of rapamycin pathway resulted in increased peptide production, antigen presentation, as well as cytotoxic T lymphocyte recognition of irradiated cells. In addition, novel proteins were made in response to γ-irradiation, resulting in new peptides presented by MHC class I molecules, which were recognized by cytotoxic T cells. We show that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue. Our findings indicate that directed radiotherapy can improve the efficacy of tumor immunotherapy.
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影响因子：
4.8
作者：
Kozjak, V;Wiedemann, N;Pfanner, N
通讯作者：
Pfanner, N
影响因子：
5.4
作者：
NEEFJES, JJ;PLOEGH, HL
通讯作者：
PLOEGH, HL
影响因子：
56.9
作者：
Altman, JD;Moss, PAH;Davis, MM
通讯作者：
Davis, MM
影响因子：
4.4
作者：
Chakraborty, M;Abrams, SI;Hodge, JW
通讯作者：
Hodge, JW
DOI：
10.1073/pnas.96.18.10326
发表时间：
1999-08-31
影响因子：
11.1
作者：
Grommé, M;Uytdehaag, FGCM;Neefjes, J
通讯作者：
Neefjes, J