Event-related potentials to threat of predictable and unpredictable shock.

Event-related potentials to threat of predictable and unpredictable shock.
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DOI:
10.1111/psyp.13206
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发表时间:
2018-10
期刊:
影响因子:
3.7
通讯作者:
Barley B
Barley B
中科院分区:
心理学3区
文献类型:
--
作者:
MacNamara A;Barley B

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认知情感神经科学任务易于管理,测量感兴趣的关键结构,可以在不同的实验室环境中使用,并使用多种心理生理学方法,可以更全面地了解影响。无威胁,可预测威胁,不可预测威胁(NPU-threat)任务评估临床和基础情感科学文献感兴趣的构念,管理相对简短,并已在实验室中使用了许多不同的测量方法(例如,惊吓眨眼,功能磁共振成像,波纹反应和主观评分)。erp提供了另一种评估npu -威胁任务期间神经生物学反应性的方法,但迄今为止,这种方法尚未得到充分利用。也就是说,目前还没有研究评估npu -威胁任务中线索引发的erp。在这里,我们对78名参与者进行了线索诱发的erp评估,这些参与者完成了npu -威胁任务的一个版本,之前的实验显示,他们的惊吓眨眼幅度是稳定的。结果显示,不可预测试验的P2振幅大于可预测试验;威胁性实验与无威胁性实验相比,前者的p3和晚期正电位(LPPs)增加,刺激前负性(SPNs)增加(主要由可预测的威胁线索驱动)。与先前的工作一致,我们观察到在威胁与无威胁试验中,在不可预测的威胁与可预测的威胁间刺激间隔中,惊吓眨眼增加。此外,与无威胁试验相比,探针引发的P3在可预测和不可预测试验中被抑制。因此,可以与npu -威胁任务(例如惊吓)中的其他措施一起记录的线索引发的erp可能为可预测和不可预测威胁处理的时间不同阶段提供有用的指标。
Cognitive affective neuroscience tasks that are straightforward to administer, measure key constructs of interest and can be used in different lab settings and with multiple psychophysiological methods can lead to a more complete understanding of effects. The No-Threat, Predictable Threat, Unpredictable Threat (NPU-threat) task assesses constructs of interest to both clinical and basic affective science literatures, is relatively brief to administer and has been used across labs with a number of different measurements (e.g., startle eyeblink, fMRI, corrugator response and subjective ratings). ERPs provide another means of assessing neurobiological reactivity during the NPU-threat task, but to date, such measures have been underutilized. That is, no study has yet evaluated cue-elicited ERPs in the NPU-threat task. Here, cue-elicited ERPs were assessed in 78 participants who completed a version of the NPU-threat task previously shown to reliably moderate startle eyeblink amplitudes. Results showed larger P2 amplitudes for unpredictable versus predictable trials; increased P3s and late positive potentials (LPPs) for threatening versus no-threat trials as well as larger stimulus preceding negativities (SPNs) for threatening versus no-threat trials (driven primarily by predictable threat cues). In line with prior work, we observed enhanced startle eyeblink for threatening versus no-threat trials and for unpredictable compared to predictable threat inter-stimulus intervals. In addition, the probe-elicited P3 was suppressed for predictable and unpredictable compared to no-threat trials. Therefore, cue-elicited ERPs, which can be recorded alongside other measures in the NPU-threat task (e.g., startle) may provide useful indices of temporally distinct stages of predictable and unpredictable threat processing.
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