Event-related potentials to threat of predictable and unpredictable shock.
Event-related potentials to threat of predictable and unpredictable shock.
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DOI:
10.1111/psyp.13206
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发表时间:
2018-10
期刊:
影响因子:
3.7
通讯作者:
Barley B
中科院分区:
文献类型:
--
作者:
MacNamara A;Barley B
Cognitive affective neuroscience tasks that are straightforward to administer, measure key constructs of interest and can be used in different lab settings and with multiple psychophysiological methods can lead to a more complete understanding of effects. The No-Threat, Predictable Threat, Unpredictable Threat (NPU-threat) task assesses constructs of interest to both clinical and basic affective science literatures, is relatively brief to administer and has been used across labs with a number of different measurements (e.g., startle eyeblink, fMRI, corrugator response and subjective ratings). ERPs provide another means of assessing neurobiological reactivity during the NPU-threat task, but to date, such measures have been underutilized. That is, no study has yet evaluated cue-elicited ERPs in the NPU-threat task. Here, cue-elicited ERPs were assessed in 78 participants who completed a version of the NPU-threat task previously shown to reliably moderate startle eyeblink amplitudes. Results showed larger P2 amplitudes for unpredictable versus predictable trials; increased P3s and late positive potentials (LPPs) for threatening versus no-threat trials as well as larger stimulus preceding negativities (SPNs) for threatening versus no-threat trials (driven primarily by predictable threat cues). In line with prior work, we observed enhanced startle eyeblink for threatening versus no-threat trials and for unpredictable compared to predictable threat inter-stimulus intervals. In addition, the probe-elicited P3 was suppressed for predictable and unpredictable compared to no-threat trials. Therefore, cue-elicited ERPs, which can be recorded alongside other measures in the NPU-threat task (e.g., startle) may provide useful indices of temporally distinct stages of predictable and unpredictable threat processing.
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