Entry of Phenuiviruses into Mammalian Host Cells.

Entry of Phenuiviruses into Mammalian Host Cells.
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DOI:
10.3390/v13020299
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发表时间:
2021-02-14
期刊:
Viruses
影响因子:
--
通讯作者:
Lozach PY
Lozach PY
中科院分区:
其他
文献类型:
--
作者:
Koch J;Xin Q;Tischler ND;Lozach PY

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伪病毒科是一个由节足动物传播的病毒大家族,全世界有100多种。其中几种会导致人类和牲畜的严重疾病。全球变暖和节肢动物病媒的明显地理扩张是认真考虑这些病毒成为新出现疾病的潜在媒介的充分理由。随着流行病的频率和数量的增加,一些phenuivirus代表了对公共和兽医健康的全球威胁。本文主要综述了在哺乳动物宿主细胞中的病毒感染的早期阶段。我们解决目前的知识,对每一个步骤的细胞进入过程中,从病毒结合到渗透到胞质溶胶。病毒受体,内吞作用和融合机制进行了讨论,根据最新进展的进入班达,静脉,和uukuviruses,这共同构成了三个突出的属Phenuiviridae家庭。
Phenuiviridae is a large family of arthropod-borne viruses with over 100 species worldwide. Several cause severe diseases in both humans and livestock. Global warming and the apparent geographical expansion of arthropod vectors are good reasons to seriously consider these viruses potential agents of emerging diseases. With an increasing frequency and number of epidemics, some phenuiviruses represent a global threat to public and veterinary health. This review focuses on the early stage of phenuivirus infection in mammalian host cells. We address current knowledge on each step of the cell entry process, from virus binding to penetration into the cytosol. Virus receptors, endocytosis, and fusion mechanisms are discussed in light of the most recent progress on the entry of banda-, phlebo-, and uukuviruses, which together constitute the three prominent genera in the Phenuiviridae family.
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