Emerging phleboviruses.

Emerging phleboviruses.
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DOI:
10.1016/j.coviro.2014.01.011
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发表时间:
2014-04
影响因子:
5.9
通讯作者:
Brennan, Benjamin
Brennan, Benjamin
中科院分区:
医学2区
文献类型:
--
作者:
Elliott, Richard M.;Brennan, Benjamin

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在中国和美国出现了新的蛇毒(布尼亚病毒科)。壁虱传播的细小病毒不编码NSM蛋白。壁虱传播的细小病毒在人类中表现出不同的致病性。布尼亚病毒科是RNA病毒中最大的一组,也可以说是最多样化的。布尼亚病毒具有真正的全球分布,可以感染脊椎动物、无脊椎动物和植物。大多数布尼亚病毒是由节肢动物传播的,因此具有在不同系统发育的宿主中复制的非凡能力。该家族提供了许多新出现的病毒的例子,包括1993年首次发现的导致美洲汉坦病毒心肺综合征的Sin Norbre和相关病毒,以及2011年在欧洲出现的导致反刍动物胎儿畸形的Schmallenberg病毒。此外,一些众所周知的本雅热病毒,如裂谷热和克里米亚-刚果出血热病毒,继续在新的地理位置出现。在这篇简短的综述中,我们集中在中国和美国新发现的与人类严重出血性疾病相关的病毒上。
New phleboviruses (family Bunyaviridae) have emerged in China and the US. Tick borne phleboviruses do not encode an NSm protein. Tick borne phleboviruses show differential pathogenicity in humans. The Bunyavidae family is the largest grouping of RNA viruses and arguably the most diverse. Bunyaviruses have a truly global distribution and can infect vertebrates, invertebrates and plants. The majority of bunyaviruses are vectored by arthropods and thus have the remarkable capability to replicate in hosts of disparate phylogeny. The family has provided many examples of emerging viruses including Sin Nombre and related viruses responsible for hantavirus cardiopulmonary syndrome in the Americas, first identified in 1993, and Schmallenberg virus which emerged in Europe in 2011, causing foetal malformations in ruminants. In addition, some well-known bunyaviruses like Rift Valley fever and Crimean-Congo haemorrhagic fever viruses continue to emerge in new geographical locations. In this short review we focus on newly identified viruses associated with severe haemorrhagic disease in humans in China and the US.
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