14-3-3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer.
14-3-3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer.
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DOI：
10.3892/ol.2014.2676
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发表时间：
2015-01
期刊：
影响因子：
2.9
通讯作者：
Zeng C
中科院分区：
文献类型：
--
作者：
Li YL;Liu L;Xiao Y;Zeng T;Zeng C
14-3-3蛋白参与多种细胞过程，包括细胞凋亡、增殖和恶性转化。14-3-3σ是14-3-3蛋白家族中的一员，在多种类型的肿瘤中起重要作用，然而，人们对14-3-3σ在胃癌中的临床意义和生物学作用知之甚少。本研究分析了14-3-3σ在胃癌中的表达模式，并探讨其与胃癌患者预后的关系。并探讨14-3-3-σ与Ki-67、Bcl2、Bax的相关性。14-3-3σ在胃癌组织中的表达水平高于正常胃组织，且14-3-3σ的表达与肿瘤大小和转移分期显著相关(P<；005)。据我们所知，目前的研究数据首次表明14-3-3σ的表达与胃癌的不良预后显著相关。此外，14-3-3σ过表达与Ki-67、Bcl2表达水平呈正相关。因此，14-3-3-σ是胃癌患者潜在的预后标志物，可能参与调控胃癌细胞的凋亡和增殖。
14-3-3 proteins participate in various cellular processes, including apoptosis, proliferation and malignant transformation. 14-3-3σ, a member of the 14-3-3 protein family, is important in several types of cancer; however, little is known about the clinical significance and biological roles of 14-3-3σ in gastric cancer. The present study analyzed the expression pattern of 14-3-3σ in gastric cancer and investigated its correlation with the prognosis of gastric cancer patients. Furthermore, the association of 14-3-3σ with Ki-67, Bcl-2 and Bax was evaluated. 14-3-3σ was expressed at higher level in gastric cancer tissue compared with healthy gastric tissue, and 14-3-3σ expression was significantly correlated with tumor size and tumor node metastasis stage (P<0.05). To the best of our knowledge, the present study data are the first to suggest that 14-3-3σ expression has been significantly associated with poor prognosis in gastric cancer. Additionally, 14-3-3σ overexpression was positively correlated with Ki-67 and Bcl-2 expression levels. Thus, 14-3-3σ is a potential prognostic marker for gastric cancer patients, and may be involved in regulating the apoptosis and proliferation of gastric cancer cells.
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影响因子：
3.5
作者：
NAKATSURU, S;YANAGISAWA, A;HORII, A
通讯作者：
HORII, A
影响因子：
3.8
作者：
Mhawech-Fauceglia, P.;Herrmann, F. R.;Odunsi, K.
通讯作者：
Odunsi, K.
影响因子：
7.4
作者：
Rosenquist, M;Alsterfjord, M;Sommarin, M
通讯作者：
Sommarin, M
王国间互补揭示了 14-3-3 蛋白的结构保守性和功能差异。
影响因子：
3.7
作者：
Lalle M;Leptourgidou F;Camerini S;Pozio E;Skoulakis EM
通讯作者：
Skoulakis EM
DOI：
10.1073/pnas.91.19.8772
发表时间：
1994-09-13
影响因子：
11.1
作者：
PARK, KC;KIM, SJ;SPORN, MB
通讯作者：
SPORN, MB