S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin.
S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin.
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DOI：
10.1002/art.24137
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发表时间：
2008-12
影响因子：
--
通讯作者：
Foell, Dirk
中科院分区：
文献类型：
--
作者：
Wittkowski, Helmut;Frosch, Michael;Wulffraat, Nico;Goldbach-Mansky, Raphaela;Kallinich, Tilmann;Kuemmerle-Deschner, Jasmin;Fruehwald, Michael C.;Dassmann, Sandra;Pham, Tuyet-Hang;Roth, Johannes;Foell, Dirk
儿童的不明原因发热(FUO)对诊断提出了挑战。鉴别诊断包括全身性幼年特发性关节炎(SJIA)，这是一种与吞噬细胞激活相关的自体炎症综合征，在出现时很难与严重的全身性感染相鉴别。在这项研究中，我们调查了吞噬细胞促炎蛋白S100A12的血清浓度是否有助于FUO患者选择抗生素或免疫抑制治疗。血清标本来自45例健康人和240例患者，其中SJIA 60例，家族性地中海热(FMF)17例，新生儿多系统炎症性疾病(NOMID)18例，Muckle Wells综合征(MWS)17例，急性淋巴细胞白血病(ALL)40例，急性髓母细胞白血病(AML)5例，全身感染83例。所有样本均在开始任何治疗前采集，并用酶联免疫吸附试验(ELISA)分析S100A12。SJIA患者血清S100A12平均水平为7,190 ng/ml(95%可信区间±2,690)，FMF为6,720 ng/ml(±4,960)，NOMID为720 ng/ml(±450)，MWS为150 ng/ml(±60)，感染组为470 ng/ml(±160)，全部为130 ng/ml(±80)，AML为45(±60)，对照组为50 ng/ml(±10)。S100A12诊断SJIA与感染的敏感性和特异性分别为66%和94%。S100A12是粒细胞活化的标志，在SJIA和FMF中高表达，这可能是这两种疾病目前尚不清楚的共同炎症机制。血清S100A12水平的测定可能为FUO的诊断提供有价值的工具。
Fever of unknown origin (FUO) in children presents a diagnostic challenge. Differential diagnosis includes Systemic Onset Juvenile Idiopathic Arthritis (SJIA), an auto-inflammatory syndrome associated with activation of phagocytic cells which at presentation is difficult to differentiate from severe systemic infections. In this study, we investigated whether serum concentrations of the phagocytic pro-inflammatory protein S100A12 may help in the decision between antibiotic or immunosuppressive therapy in patients with FUO. Serum samples were obtained from 45 healthy controls and 240 patients: 60 had SJIA, 17 Familial Mediterranean Fever (FMF), 18 Neonatal-Onset Multisystem Inflammatory Disease (NOMID), 17 Muckle Wells Syndrome (MWS), 40 Acute Lymphoblastic Leukemia (ALL), 5 Acute Myeloblastic Leukemia (AML), and 83 systemic infections. All samples were collected at presentation before initiation of anytreatment, and were analyzed for S100A12 by ELISA. In SJIA patients the mean S100A12 serum level was 7,190 ng/ml (95% confidence interval ±2,690), in FMF 6,720 ng/ml (±4,960), in NOMID 720 ng/ml (±450), in MWS 150 ng/ml (±60), in infections 470 ng/ml (±160), in ALL 130 ng/ml (±80), and in AML 45 (±60) compared to 50 ng/ml (±10) in healthy controls. Sensitivity and specificity of S100A12 to distinguish SJIA from infections were 66% and 94% respectively. S100A12, a marker of granulocyte activation, is highly overexpressed in SJIA and FMF, which may point to so far unknown common inflammatory mechanisms in these diseases. The measurement of S100A12 serum levels may provide a valuable diagnostic tool in the evaluation of FUO.
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影响因子：
27.4
作者：
Federici, L.;Rittore-Domingo, C.;Touitou, I.
通讯作者：
Touitou, I.
影响因子：
7.3
作者：
Foell, D;Hernández-Rodríguez, J;Roth, J
通讯作者：
Roth, J
影响因子：
--
作者：
Ogilvie, Emma Mary;Khan, Arshad;Woo, Patricia
通讯作者：
Woo, Patricia
DOI：
10.1084/jem.20050473
发表时间：
2005-05-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Pascual V;Allantaz F;Arce E;Punaro M;Banchereau J
通讯作者：
Banchereau J
阻塞系统性炎症中的IL-1。
影响因子：
15.3
作者：
Dinarello, Charles A
通讯作者：
Dinarello, Charles A