Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.
Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.
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DOI：
10.1016/j.jaac.2022.05.014
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发表时间：
2023-03
影响因子：
13.3
通讯作者：
Tseng, Wan-Ling
中科院分区：
文献类型：
--
作者：
Lee, Ka Shu;Hagan, Cheyanne N.;Hughes, Mina;Cotter, Grace;Freud, Eva McAdam;Kircanski, Katharina;Leibenluft, Ellen;Brotman, Melissa A.;Tseng, Wan-Ling
儿童期易激惹，表现为与同龄人不成比例的频繁发脾气和低挫折耐受力，是许多儿科疾病的转诊断症状。使用任务依赖性功能性磁共振成像（fMRI）来探测易怒中的神经功能障碍的研究已经增加。然而，一个综合性的审查，总结已发表的方法和合成功能磁共振成像结果仍然缺乏。我们于2021年3月在关键数据库中使用易激惹术语和任务功能神经影像学进行了系统检索，并确定了30项研究进行系统综述。总结了样本特征和功能磁共振成像方法。28项研究的子集符合提取基于坐标的数据进行定量荟萃分析的标准。十激活可能性估计进行了检查神经收敛的刺激性措施和功能磁共振成像任务域。系统评价显示样本量较小（中位数= 58，平均年龄范围= 8-16岁），样本特征、应激指标、任务和分析方法均不均匀。荟萃分析发现，在与情绪反应、认知控制和奖励处理相关的神经认知功能中，或在每个领域内，没有证据表明易怒的神经激活收敛。敏感性分析偏出的异质性任务，易怒的措施，刺激类型和发展年龄驱动的方差都产生了零的结果。结果进行了比较，从11项研究的易怒相关的结构异常的审查。神经会聚的缺乏表明，需要共同的，标准化的易怒评估和更均匀的功能磁共振成像任务。设计合理的功能磁共振成像研究探讨通常定义的神经认知功能可能会更富有成效地阐明易怒的神经机制。开放科学实践、大型神经科学数据库中的数据挖掘和标准化的分析方法促进了易怒研究中有意义的合作。
Childhood irritability, operationalized as disproportionate and frequent temper tantrums and low frustration tolerance relative to peers, is a transdiagnostic symptom across many pediatric disorders. Studies using task-dependent functional magnetic resonance imaging (fMRI) to probe neural dysfunction in irritability have increased. However, an integrated review summarizing the published methods and synthesized fMRI results remains lacking. We conducted a systematic search using irritability terms and task functional neuroimaging in key databases in March 2021, and identified 30 studies for our systematic review. Sample characteristics and fMRI methods were summarized. A subset of 28 studies met the criteria for extracting coordinate-based data for quantitative meta-analysis. Ten activation-likelihood estimations were performed to examine neural convergence across irritability measures and fMRI task domains. Systematic review revealed small sample sizes (median = 58, mean age range = 8–16 years) with heterogeneous sample characteristics, irritability measures, tasks, and analytical procedures. Meta-analyses found no evidence for neural activation convergence of irritability across neurocognitive functions related to emotional reactivity, cognitive control, and reward processing, or within each domain. Sensitivity analyses partialing out variances driven by heterogeneous tasks, irritability measures, stimulus types, and developmental ages all yielded null findings. Results were compared with a review on irritability-related structural anomalies from 11 studies. The lack of neural convergence suggests a need for common, standardized irritability assessments and more homogeneous fMRI tasks. Thoughtfully designed fMRI studies probing commonly defined neurocognitive functions may be more fruitful to elucidate the neural mechanisms of irritability. Open science practices, data mining in large neuroscience databases, and standardized analytical methods promote meaningful collaboration in irritability research.
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