Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice.
Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice.
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DOI：
10.1016/j.resp.2014.09.006
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发表时间：
2014-12-01
影响因子：
2.3
通讯作者：
Lewis, Stephen J.
中科院分区：
文献类型：
--
作者：
Getsy, Paulina M.;Davis, Jesse;Coffee, Gregory A.;May, Walter J.;Palmer, Lisa A.;Strohl, Kingman P.;Lewis, Stephen J.
C57BL6小鼠在清醒和睡眠期间表现出非窒息性呼吸和自发性呼吸暂停，并在缺氧挑战停止后出现明显的呼吸障碍。我们检验了(1)C57BL6小鼠在高碳酸血症或低氧-高碳酸血症刺激后是否表现出明显的非缺氧性呼吸，(2)比较了C57BL6小鼠与B6AF1 （57BL6 dam × A/J）和Swiss-Webster小鼠的缺氧后非缺氧性呼吸变化，这两种小鼠表现出与C57BL6小鼠不同的通气反应。C57BL6小鼠在低氧（10% O2, 90% N2）、高碳酸（5% CO2, 21% O2, 74% N2）和低氧-高碳酸（10% O2, 5% CO2, 85% N2）挑战后返回室内空气后，呼吸频率和非缺氧呼吸明显增加。B6AF1小鼠在缺氧后表现出较少的呼吸急促和减少的非窒息性呼吸，而Swiss-Webster小鼠在缺氧后表现出强烈的呼吸急促和轻微的非窒息性呼吸增加。这些研究表明，C57BL6小鼠在生理相关的低氧-高碳酸血症刺激后非肾性呼吸增加，并表明对这些小鼠和B6AF1和Swiss-Webster小鼠的进一步研究将有助于确定非肾性呼吸的遗传学。
C57BL6 mice display non-eupneic breathing and spontaneous apneas during wakefulness and sleep as well as markedly disordered breathing following cessation of a hypoxic challenge. We examined whether (1) C57BL6 mice display marked non-eupneic breathing following hypercapnic or hypoxic-hypercapnic challenges, and (2) compared the post-hypoxia changes in non-eupneic breathing of C57BL6 mice to those of B6AF1 (57BL6 dam × A/J sire) and Swiss-Webster mice, which display different ventilatory responses than C57BL6 mice. C57BL6 mice displayed marked increases in respiratory frequency and non-eupneic breathing upon return to room-air after hypoxic (10% O2, 90% N2), hypercapnic (5% CO2, 21% O2, 74% N2) and hypoxic-hypercapnic (10% O2, 5% CO2, 85% N2) challenges. B6AF1 mice displayed less tachypnea and reduced non-eupneic breathing post-hypoxia, whereas Swiss-Webster mice displayed robust tachypnea with minimal increases in non-eupneic breathing post-hypoxia. These studies demonstrate that non-eupneic breathing increases after physiologically-relevant hypoxic-hypercapnic challenge in C57BL6 mice and suggest that further studies with these and B6AF1 and Swiss-Webster mice will help define the genetics of non-eupneic breathing.
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影响因子：
3.3
作者：
Gaston, Benjamin;May, Walter J.;Lewis, Stephen J.
通讯作者：
Lewis, Stephen J.
影响因子：
--
作者：
Garcia, Alfredo J., III;Zanella, Sebastien;Koch, Henner;Doi, Atsushi;Ramirez, Jan-Marino
通讯作者：
Ramirez, Jan-Marino
影响因子：
3.3
作者：
EPSTEIN, RA;EPSTEIN, MAF;MELLINS, RB
通讯作者：
MELLINS, RB
影响因子：
5.5
作者：
Huda, Rafiq;Pollema-Mays, Sarah L.;Martina, Marco
通讯作者：
Martina, Marco
影响因子：
4.6
作者：
Campen, MJ;Tagaito, Y;O'Donnell, CP
通讯作者：
O'Donnell, CP