Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility.
Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility.
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DOI：
10.1038/nnano.2010.153
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发表时间：
2010-09
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
作者：
可溶碳纳米管是一种很有前途的体内递送和成像应用材料。一些报告描述了碳纳米管的体内毒性，然而，它们对男性生殖的影响还没有被研究过。在这里，我们表明，反复静脉注射水溶性多壁碳纳米管到雄性小鼠体内可以导致可逆性睾丸损伤，而不影响生育能力。第15天，纳米管在睾丸中聚集，产生氧化应激，睾丸生精上皮厚度减少，但在60天和90天后，损伤被修复。在整个90天期间，精子的数量、质量和完整性以及三种主要性激素的水平都没有受到显著影响。经处理的雄性小鼠的生育力不受影响；与经处理的雄性小鼠交配的雌性小鼠与未经处理的雄性小鼠交配的雌性小鼠的妊娠率和分娩成功率没有差异。
Soluble carbon nanotubes are promising materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, however, their effects on male reproduction have not been examined. Here we show that repeated intravenous injections of water-soluble multi-walled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress, and decreased the thickness of the seminiferous epithelium in the testis at day 15, but the damage was repaired after 60 and 90 days. The quantity, quality, and integrity of the sperm and the levels of three major sex hormones were not significantly affected throughout the 90-day period. The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice.
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影响因子：
13
作者：
Li, Michelle W. M.;Mruk, Dolores D.;Lee, Will M.;Cheng, C. Yan
通讯作者：
Cheng, C. Yan
影响因子：
15
作者：
Chen, Jingyi;Chen, Shuyi;Zhao, Xianrui;Kuznetsova, Larisa V.;Wong, Stanislaus S.;Ojima, Iwao
通讯作者：
Ojima, Iwao
影响因子：
10.4
作者：
Li Z;Hulderman T;Salmen R;Chapman R;Leonard SS;Young SH;Shvedova A;Luster MI;Simeonova PP
通讯作者：
Simeonova PP
影响因子：
10.8
作者：
Manna, SK;Sarkar, S;Ramesh, GT
通讯作者：
Ramesh, GT
影响因子：
2.1
作者：
Li, ChunMei;Taneda, Shinji;Suzuki, Akira K.
通讯作者：
Suzuki, Akira K.