Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence.
Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence.
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DOI：
10.1037/a0014657
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发表时间：
2009-02
影响因子：
4.6
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Young, Susan E.;Friedman, Naomi P.;Miyake, Akira;Willcutt, Erik G.;Corley, Robin P.;Haberstick, Brett C.;Hewitt, John K.
行为去抑制被描述为对外化障碍的普遍脆弱性。尽管越来越多的证据表明其有效性和遗传性，整个青春期的行为去抑制的结构稳定性及其与执行功能的关系的强度和病因尚未研究。在这项多变量双胞胎研究中，作者评估了12岁和17岁时的行为去抑制，包括物质使用，行为障碍，注意力缺陷/多动障碍（ADHD）和新奇寻求。执行功能在17岁时进行了基于实验室的认知任务评估。结果表明，在12岁时，行为去抑制主要是多动症和行为问题，是高度遗传的。在17岁时，4个组成部分的贡献更加平衡，遗传因素引起的方差比例较小，由于共同的环境影响而产生额外的方差。在这两个年龄段，行为去抑制与反应抑制的关系比其他执行功能（工作记忆更新和任务集转移）更密切，这种关系主要是遗传起源。这些结果突出了整个青春期的行为去抑制的动态性质，并表明反应抑制可能是一个重要的机制潜在的脆弱性去抑制精神病理学。
Behavioral disinhibition has been characterized as a generalized vulnerability to externalizing disorders. Despite increasing evidence for its validity and heritability, the structural stability of behavioral disinhibition across adolescence and the strength and etiology of its relation to executive functions have not been studied. In this multivariate twin study, the authors assessed behavioral disinhibition using measures tapping substance use, conduct disorder, attention-deficit/hyperactivity disorder (ADHD), and novelty seeking at ages 12 and 17. Executive functions were assessed with laboratory-based cognitive tasks at age 17. Results indicated that, at age 12, behavioral disinhibition was dominated by ADHD and conduct problems and was highly heritable. At age 17, the contributions of the 4 components were more balanced, and the proportion of variance attributable to genetic factors was somewhat smaller, with additional variance due to shared environmental influences. At both ages, behavioral disinhibition was more closely related to response inhibition than other executive functions (working memory updating and task-set shifting), and this relationship was primarily genetic in origin. These results highlight the dynamic nature of behavioral disinhibition across adolescence and suggest that response inhibition may be an important mechanism underlying vulnerability to disinhibitory psychopathology.
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DOI：
10.3758/bf03204507
发表时间：
1993-05-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
COHEN, J;MACWHINNEY, B;PROVOST, J
通讯作者：
PROVOST, J
影响因子：
--
作者：
Elkins, Irene J.;McGue, Matt;Iacono, William G.
通讯作者：
Iacono, William G.
影响因子：
3
作者：
Bishop, EG;Cherny, SS;Hewitt, JK
通讯作者：
Hewitt, JK
DOI：
10.1111/j.1530-0277.2002.tb02524.x
发表时间：
2002-02-01
影响因子：
3.2
作者：
Finn, PR;Mazas, CA;Steinmetz, J
通讯作者：
Steinmetz, J
影响因子：
3.6
作者：
FERGUSSON, DM;HORWOOD, LJ;LYNSKEY, MT
通讯作者：
LYNSKEY, MT