Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum.
Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum.
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DOI：
10.1007/s12015-021-10118-w
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发表时间：
2021-08
影响因子：
4.8
通讯作者：
Arai K
中科院分区：
文献类型：
--
作者：
Takase H;Hamanaka G;Ohtomo R;Park JH;Chung KK;Gelman IH;Kim KW;Lok J;Lo EH;Arai K
胼胝体在出生后时期的形成对于正常的神经功能至关重要，临床遗传学研究已经确定了6 q24 -25微缺失在这个过程中的关联。然而，胼胝体形成的机制及其关键基因尚未完全理解或确定。在这项研究中，我们研究了AKAP 12在出生后胼胝体形成的作用，重点是神经胶质细胞的发育，因为AKAP 12是6q25.1编码，最近已被证明在神经胶质功能的调节中发挥作用。在小鼠中，AKAP 12的表达水平被证实是更大的胼胝体相比，皮质，AKAP 12水平随着年龄的增长，胼胝体和皮质区域。此外，星形胶质细胞在出生后的胼胝体中表达AKAP 12，但少突胶质细胞前体细胞（OPCs），另一种主要类型的神经胶质细胞在发育中的胼胝体，没有。此外，与野生型相比，Akap 12基因敲除小鼠的星形胶质细胞和OPCs数量较少，出生后胼胝体发育也沿着减慢。这些研究结果表明，AKAP 12信号可能需要通过细胞和非细胞自主机制在胼胝体中的出生后胶质细胞的形成。
The formation of the corpus callosum in the postnatal period is crucial for normal neurological function, and clinical genetic studies have identified an association of 6q24–25 microdeletion in this process. However, the mechanisms underlying corpus callosum formation and its critical gene(s) are not fully understood or identified. In this study, we examined the roles of AKAP12 in postnatal corpus callosum formation by focusing on the development of glial cells, because AKAP12 is coded on 6q25.1 and has recently been shown to play roles in the regulations of glial function. In mice, the levels of AKAP12 expression was confirmed to be larger in the corpus callosum compared to the cortex, and AKAP12 levels decreased with age both in the corpus callosum and cortex regions. In addition, astrocytes expressed AKAP12 in the corpus callosum after birth, but oligodendrocyte precursor cells (OPCs), another major type of glial cell in the developing corpus callosum, did not. Furthermore, compared to wild types, Akap12 knockout mice showed smaller numbers of both astrocytes and OPCs, along with slower development of corpus callosum after birth. These findings suggest that AKAP12 signaling may be required for postnatal glial formation in the corpus callosum through cell- and non-cell autonomous mechanisms.
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影响因子：
9.2
作者：
Gelman, Irwin H.
通讯作者：
Gelman, Irwin H.
影响因子：
5.2
作者：
Nagamani, Sandesh Chakravarthy Sreenath;Erez, Ayelet;Cheung, Sau Wai
通讯作者：
Cheung, Sau Wai
影响因子：
2.9
作者：
Reemst K;Noctor SC;Lucassen PJ;Hol EM
通讯作者：
Hol EM
影响因子：
2.5
作者：
Maki T;Maeda M;Uemura M;Lo EK;Terasaki Y;Liang AC;Shindo A;Choi YK;Taguchi A;Matsuyama T;Takahashi R;Ihara M;Arai K
通讯作者：
Arai K
影响因子：
2
作者：
Bisgaard, Anne-Marie;Kirchhoff, Maria;Skovby, Flemming
通讯作者：
Skovby, Flemming