Early life stress and glutamate neurotransmission in major depressive disorder.
Early life stress and glutamate neurotransmission in major depressive disorder.
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DOI：
10.1016/j.euroneuro.2020.03.015
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Sanacora G
中科院分区：
文献类型：
--
作者：
Averill LA;Abdallah CG;Fenton LR;Fasula MK;Jiang L;Rothman DL;Mason GF;Sanacora G
早期生活应激(ELS)和谷氨酸神经传递与抑郁症(MDD)的病理生理有关。在非人类灵长类动物中，ELS与皮质GLX(即谷氨酸+谷氨酰胺)呈正相关。然而，成年MDD患者ELS与皮质谷氨酸的关系尚不完全清楚。应用~1H磁共振波谱(MRS)对36例未用药的MDD患者的枕叶皮质谷氨酸和谷氨酰胺水平进行了探索性分析。在一个子样本(n=11)中，我们使用先进的~(13)C MRS方法测量了动态谷氨酸/谷氨酰胺循环(VCycle)。使用早期生活创伤问卷(ETI)评估ELS病史。探索性分析表明内毒素和谷氨酰胺之间存在关系，这反映在内毒素评分与枕叶谷氨酰胺呈显著正相关(r=0.39，p=0.017)，而与谷氨酸无关。事后分析表明，与谷氨酰胺的联系是由ETI情绪虐待(ETI-EA)子量表驱动的(rS=0.39，p=0.02)。V周期与ETI呈趋势性相关(rs0.55，p=0.087)，与eTi-Ea显著相关(rs0.67，p=0.03)。在这个小样本的MDD患者中，那些有童年情感虐待的人似乎增加了枕骨谷氨酸神经传递，这反映在谷氨酸/谷氨酰胺循环和谷氨酰胺水平的增加上。还需要进一步的研究来证实这一先导证据，并检查ELS对谷氨酸神经传递的影响是否构成ELS与精神病理学之间关系的基础。
Early life stress (ELS) and glutamate neurotransmission have been implicated in the pathophysiology of major depressive disorder (MDD). In non-human primates, ELS was positively correlated with cortical Glx (i.e., glutamate + glutamine). However, the relationship between ELS and cortical glutamate in adult patients with MDD is not fully known. Using 1H Magnetic Resonance Spectroscopy (MRS), we conducted exploratory analyses measuring occipital cortical glutamate and glutamine levels in 36 medication-free patients with MDD. In a subsample (n = 11), we measured dynamic glutamate/glutamine cycling (Vcycle) using advanced 13C MRS methods. ELS history was assessed using Early-life Trauma Inventory (ETI). Exploratory analyses suggest a relationship between ETI and glutamine as reflected by a significant positive correlation between ETI scores and occipital glutamine (rs = 0.39, p = 0.017) but not glutamate. Post-hoc analyses showed that the association with glutamine was driven by the ETI emotional abuse (ETI-EA) subscale (rs = 0.39, p = 0.02). Vcycle correlation with ETI was at trend level (rs = 0.55, p = 0.087) and significantly correlated with ETI-EA (rs = 0.67, p = 0.03). In this small sample of patients with MDD, those with childhood emotional abuse appear to have increased occipital glutamate neurotransmission as reflected by increased glutamate/glutamine cycling and glutamine level. Future studies would be needed to confirm this pilot evidence and to examine whether ELS effects on glutamate neurotransmission underlie the relationship between ELS and psychopathology.
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影响因子：
13.5
作者：
Abdallah CG;Sanacora G;Duman RS;Krystal JH
通讯作者：
Krystal JH
战斗暴露的严重程度与战斗退伍军人的皮质厚度降低有关：初步报告。
DOI：
10.1177/2470547017724714
发表时间：
2017-01
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
Averill LA;Abdallah CG;Pietrzak RH;Averill CL;Southwick SM;Krystal JH;Harpaz-Rotem I
通讯作者：
Harpaz-Rotem I
影响因子：
22.8
作者：
Abdallah CG;Niciu MJ;Fenton LR;Fasula MK;Jiang L;Black A;Rothman DL;Mason GF;Sanacora G
通讯作者：
Sanacora G
影响因子：
4.8
作者：
Frodl, Thomas;Reinhold, Elena;Meisenzahl, Eva M.
通讯作者：
Meisenzahl, Eva M.
影响因子：
10.6
作者：
Auer, DP;Pütz, B;Holsboer, F
通讯作者：
Holsboer, F