Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection.
Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection.
复制标题
滤泡辅助 T 细胞促进日本血吸虫感染期间小鼠的肝脏病理学
DOI：
10.1371/journal.ppat.1004097
复制
发表时间：
2014-05
期刊：
影响因子：
6.7
通讯作者：
Su C
中科院分区：
文献类型：
--
作者：
Chen X;Yang X;Li Y;Zhu J;Zhou S;Xu Z;He L;Xue X;Zhang W;Dong X;Wu H;Li CJ;Hsu HT;Kong W;Liu F;Tripathi PB;Yu MS;Chang J;Zhou L;Su C
日本血吸虫（Schistosoma japonicum，S.日本血吸虫）感染时，在疾病的急性阶段，肉芽肿反应由寄生虫卵捕获在宿主器官中，特别是在肝脏中诱导。而过度的肝肉芽肿反应可导致慢性感染宿主更严重的纤维化和循环障碍。然而，肝肉芽肿形成的确切机制仍不清楚。在这项研究中，我们首次发现滤泡辅助性T（Tfh）细胞被募集到肝脏，上调肝肉芽肿形成和肝损伤。日本血吸虫感染的小鼠，并确定了一种新的功能，巨噬细胞在Tfh细胞诱导。此外，我们的研究结果表明，由巨噬细胞驱动的Tfh细胞的产生依赖于细胞-细胞接触和巨噬细胞上的诱导型共刺激配体（ICOSL）的水平，其受CD40-CD40L信号转导的调节。我们的研究结果揭示了Tfh细胞在S.日本血吸虫感染小鼠。
Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. However, the exact mechanism of hepatic granuloma formation has remained obscure. In this study, we for the first time showed that follicular helper T (Tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in S. japonicum-infected mice, and identified a novel function of macrophages in Tfh cell induction. In addition, our results showed that the generation of Tfh cells driven by macrophages is dependent on cell–cell contact and the level of inducible costimulator ligand (ICOSL) on macrophages which is regulated by CD40–CD40L signaling. Our findings uncovered a previously unappreciated role for Tfh cells in liver pathology caused by S. japonicum infection in mice.
登录
查看更多内容
影响因子：
30.5
作者：
Butler, Noah S.;Moebius, Jacqueline;Pewe, Lecia L.;Traore, Boubacar;Doumbo, Ogobara K.;Tygrett, Lorraine T.;Waldschmidt, Thomas J.;Crompton, Peter D.;Harty, John T.
通讯作者：
Harty, John T.
DOI：
10.1084/jem.20101773
发表时间：
2011-05-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fahey LM;Wilson EB;Elsaesser H;Fistonich CD;McGavern DB;Brooks DG
通讯作者：
Brooks DG
影响因子：
3.7
作者：
Ji F;Liu Z;Cao J;Li N;Liu Z;Zuo J;Chen Y;Wang X;Sun J
通讯作者：
Sun J
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
6.7
作者：
Broadhurst MJ;Leung JM;Lim KC;Girgis NM;Gundra UM;Fallon PG;Premenko-Lanier M;McKerrow JH;McCune JM;Loke P
通讯作者：
Loke P