B cell response is required for granuloma formation in the early infection of Schistosoma japonicum.
B cell response is required for granuloma formation in the early infection of Schistosoma japonicum.
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DOI：
10.1371/journal.pone.0001724
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发表时间：
2008-03-05
期刊：
影响因子：
3.7
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Ji F;Liu Z;Cao J;Li N;Liu Z;Zuo J;Chen Y;Wang X;Sun J
血吸虫虫卵诱导的肝肉芽肿是一种动态的炎症反应，是由对感染的复杂免疫反应引起的。然而，B细胞在炎性肉芽肿发展中的作用尚未完全清楚。我们在这里报告说，S需要B细胞功能。日本血吸虫虫卵感染早期肉芽肿病理。与野生型小鼠相比，OBF-1敲除小鼠和µMT小鼠在感染后5周发生严重减少的肝肉芽肿。相比之下，它们在感染后8周的肉芽肿病理学上没有显着差异。此外，我们发现B细胞和抗体在感染早期在野生型小鼠的肉芽肿中积累，表明B细胞应答对肉芽肿性炎症的贡献。此外，B细胞功能缺陷显著降低肝卵负荷。这些结果表明B细胞在早期肉芽肿病理学中发挥重要作用。令人惊讶的是，我们发现S。日本血吸虫感染破坏了淋巴滤泡的结构。这种破坏性作用与卵清蛋白攻击后严重受损的T细胞依赖性抗体应答相关。因此，这些发现揭示了血吸虫和宿主免疫系统之间相互作用的新方面。
Schistosoma egg-induced liver granuloma is a dynamic inflammatory reaction that results from complex immune responses to the infection. However, the role of B cells in inflammatory granuloma development is not yet fully understood. We report here that B cell function is required for S. japonicum egg-induced granuloma pathology in early infection. Both OBF-1 knockout mice and µMT mice develop severely reduced hepatic granulomas at five weeks post-infection compared to their wild-type counterparts. In contrast, they display no significant difference in granuloma pathology at eight weeks post-infection. Moreover, we find that B cells and antibodies accumulate in the granulomas of wild-type mice early in the infection, indicating a contribution of the B cell response to the granulomatous inflammation. Furthermore, defects in B cell function markedly reduce liver egg burden. These results suggest an important role for B cells in early granuloma pathology. Surprisingly, we found that the S. japonicum infection destroys the structure of the lymphoid follicles. This disruptive effect is correlated with a severely impaired T cell-dependent antibody response upon challenge with ovalbumin. Thus, these findings reveal a novel aspect of the interaction between Schistosoma and the host immune system.
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影响因子：
15.3
作者：
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影响因子：
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