Association of Kidney Function With NMR-Quantified Lipids, Lipoproteins, and Metabolic Measures in Mexican Adults.
Association of Kidney Function With NMR-Quantified Lipids, Lipoproteins, and Metabolic Measures in Mexican Adults.
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DOI：
10.1210/clinem/dgab497
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发表时间：
2021-09-27
期刊：
影响因子：
--
通讯作者：
Tapia-Conyer R
中科院分区：
文献类型：
--
作者：
Aguilar-Ramirez D;Alegre-Díaz J;Herrington WG;Staplin N;Ramirez-Reyes R;Gnatiuc L;Hill M;Romer F;Torres J;Trichia E;Wade R;Collins R;Emberson JR;Kuri-Morales P;Tapia-Conyer R
慢性肾脏疾病(CKD)和糖尿病与血脂异常、代谢异常和动脉粥样硬化风险相关。与传统的分析方法相比，核磁共振波谱提供了更多关于脂蛋白的详细信息。在来自墨西哥城前瞻性研究的大约38,000名参与者中，年龄在35岁到84岁之间，没有使用降脂药物，核磁共振波谱量化了血浆中脂蛋白颗粒的浓度、它们的脂质组成和其他代谢指标。在对混杂因素和多样性进行调整后，每项核磁共振测量与较低的估计肾小球滤过率(EGFR；<；60毫升/分钟/1.73平方米)相关的线性回归。对患有和不患有糖尿病的人分别进行了分析。在38081名受试者(平均年龄52岁，为女性)中，糖尿病组和非糖尿病组中EGFR降低的比例分别为4.8%(306/6403)和1.2%(365/31678)。在糖尿病患者和非糖尿病患者中，EGFR降低与58项核磁共振指标的水平显著相关，这些指标包括载脂蛋白B(Apo-B)、大多数含Apo-B的脂蛋白的颗粒数量、这些脂蛋白中携带的胆固醇和甘油三酯、几种脂肪酸、总胆碱和磷脂酰胆碱、柠檬酸盐、谷氨酰胺、苯丙氨酸、β-OH-丁酸盐和炎症指标糖蛋白-A，而13项核磁共振指标显著降低，包括中、小型高密度脂蛋白颗粒、极低密度脂蛋白颗粒大小、饱和：总脂肪酸、缬氨酸、酪氨酸和醋酸甘油酯的比率。在这些肥胖和糖尿病水平较高的墨西哥人中，无论是否患有糖尿病，肾功能低下都与血脂和代谢特征的广泛变化有关。这些改变可能有助于解释慢性肾脏病患者较高的动脉粥样硬化风险。
Chronic kidney disease (CKD) and diabetes are associated with dyslipidemia, metabolic abnormalities, and atherosclerotic risk. Nuclear magnetic resonance (NMR) spectroscopy provides much more detail on lipoproteins than traditional assays. In about 38 000 participants from the Mexico City Prospective Study, aged 35 to 84 years and not using lipid-lowering medication, NMR spectroscopy quantified plasma concentrations of lipoprotein particles, their lipidic compositions, and other metabolic measures. Linear regression related low estimated glomerular filtration rate (eGFR; <60 mL/min/1.73 m2) to each NMR measure after adjustment for confounders and for multiplicity. Analyses were done separately for those with and without diabetes. Among the 38 081 participants (mean age 52 years, 64% women), low eGFR was present for 4.8% (306/6403) of those with diabetes and 1.2% (365/31 678) of those without diabetes. Among both those with and without diabetes, low eGFR was significantly associated with higher levels of 58 NMR measures, including apolipoprotein B (Apo-B), the particle numbers of most Apo-B containing lipoproteins, the cholesterol and triglycerides carried in these lipoproteins, several fatty acids, total cholines and phosphatidylcholine, citrate, glutamine, phenylalanine, β-OH-butyrate, and the inflammatory measure glycoprotein-A, and significantly lower levels of 13 NMR measures, including medium and small high-density lipoprotein particle measures, very low-density lipoprotein particle size, the ratio of saturated:total fatty acids, valine, tyrosine, and aceto-acetate. In this Mexican population with high levels of adiposity and diabetes, low kidney function was associated with widespread alterations in lipidic and metabolic profiles, both in those with and without diabetes. These alterations may help explain the higher atherosclerotic risk experienced by people with CKD.
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影响因子：
30.8
作者：
Kettunen, Johannes;Tukiainen, Taru;Sarin, Antti-Pekka;Ortega-Alonso, Alfredo;Tikkanen, Emmi;Lyytikainen, Leo-Pekka;Kangas, Antti J.;Soininen, Pasi;Wuertz, Peter;Silander, Kaisa;Dick, Danielle M.;Rose, Richard J.;Savolainen, Markku J.;Viikari, Jorma;Kahonen, Mika;Lehtimaki, Terho;Pietilainen, Kirsi H.;Inouye, Michael;McCarthy, Mark I.;Jula, Antti;Eriksson, Johan;Raitakari, Olli T.;Salomaa, Veikko;Kaprio, Jaakko;Jarvelin, Marjo-Riitta;Peltonen, Leena;Perola, Markus;Freimer, Nelson B.;Ala-Korpela, Mika;Palotie, Aarno;Ripatti, Samuli
通讯作者：
Ripatti, Samuli
影响因子：
4.6
作者：
Barrios C;Zierer J;Würtz P;Haller T;Metspalu A;Gieger C;Thorand B;Meisinger C;Waldenberger M;Raitakari O;Lehtimäki T;Otero S;Rodríguez E;Pedro-Botet J;Kähönen M;Ala-Korpela M;Kastenmüller G;Spector TD;Pascual J;Menni C
通讯作者：
Menni C
DOI：
10.1016/s2213-8587(18)30050-0
发表时间：
2018-06
期刊：
The lancet. Diabetes & endocrinology
影响因子：
--
作者：
Herrington WG;Alegre-Díaz J;Wade R;Gnatiuc L;Ramirez-Reyes R;Hill M;Solano-Sánchez M;Baigent C;Lewington S;Collins R;Tapia-Conyer R;Peto R;Kuri-Morales P;Emberson JR
通讯作者：
Emberson JR
影响因子：
158.5
作者：
通讯作者：
--
影响因子：
5.4
作者：
Akinkuolie, Akintunde O.;Buring, Julie E.;Mora, Samia
通讯作者：
Mora, Samia