A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides.
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides.
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DOI：
10.3390/ijms21197047
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发表时间：
2020-09-24
影响因子：
5.6
通讯作者：
Kumar N
中科院分区：
文献类型：
--
作者：
Browne K;Chakraborty S;Chen R;Willcox MD;Black DS;Walsh WR;Kumar N
抗生素耐药性是一个多方面的危机，对全球健康构成严重威胁。传统的抗生素管道已经耗尽，促使人们研究替代的抗菌策略。受自然界的启发，抗菌肽因其临床潜力而迅速受到关注，因为它们与传统抗生素相比具有明显的优势。抗菌肽存在于所有形式的生命中，并在先天免疫系统中发挥关键作用。许多抗菌肽在进化上是保守的，具有有限的耐药性倾向。此外，对肽骨架的化学修饰可用于改善生物活性和稳定性并降低毒性。这篇综述详细介绍了基于肽的抗菌剂的治疗潜力，以及临床转化所需克服的挑战。我们探讨了拟议的活性机制，合成仿生学的设计，以及这类新型抗菌化合物如何满足对有效抗生素的需求。最后，我们讨论了市售肽类抗菌药物和抗菌肽的临床试验。
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health. The traditional antibiotic pipeline has been exhausted, prompting research into alternate antimicrobial strategies. Inspired by nature, antimicrobial peptides are rapidly gaining attention for their clinical potential as they present distinct advantages over traditional antibiotics. Antimicrobial peptides are found in all forms of life and demonstrate a pivotal role in the innate immune system. Many antimicrobial peptides are evolutionarily conserved, with limited propensity for resistance. Additionally, chemical modifications to the peptide backbone can be used to improve biological activity and stability and reduce toxicity. This review details the therapeutic potential of peptide-based antimicrobials, as well as the challenges needed to overcome in order for clinical translation. We explore the proposed mechanisms of activity, design of synthetic biomimics, and how this novel class of antimicrobial compound may address the need for effective antibiotics. Finally, we discuss commercially available peptide-based antimicrobials and antimicrobial peptides in clinical trials.
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