Erythropoietin in Lupus: Unanticipated Immune Modulating Effects of a Kidney Hormone.
Erythropoietin in Lupus: Unanticipated Immune Modulating Effects of a Kidney Hormone.
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DOI：
10.3389/fimmu.2021.639370
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发表时间：
2021
影响因子：
7.3
通讯作者：
Cravedi P
中科院分区：
文献类型：
--
作者：
Eswarappa M;Cantarelli C;Cravedi P
系统性红斑狼疮(SLE)是一种临床表现多样的多器官自身免疫性疾病，以复发缓解为特征。SLE的发病机制是多因素的，包括遗传、环境和激素因素，导致对自身抗原的耐受性丧失和自身抗体的产生。系统性红斑狼疮患者的死亡率仍然显著高于普通人群，部分原因是现有治疗方法的疗效有限以及相关的毒性。因此，迫切需要新的靶向治疗来改善受影响个人的结果。促红细胞生成素(EPO)是一种肾脏产生的激素，可以促进红细胞在缺氧时的产生，最近被证明也具有非红细胞生成特性，包括免疫调节作用。在自身免疫性疾病的各种模型中，EPO限制细胞凋亡，促进细胞清除，同时减少促炎细胞因子，促进调节性T细胞的诱导。值得注意的是，EPO已被证明可以降低SLE小鼠模型的自身免疫反应和疾病严重程度。在此，我们综述了EPO的非红细胞生成作用，特别是对SLE的免疫调节作用及其潜在的临床应用。
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease with variable clinical presentation, typically characterized by a relapsing-remitting course. SLE has a multifactorial pathogenesis including genetic, environmental, and hormonal factors that lead to loss of tolerance against self-antigens and autoantibody production. Mortality in SLE patients remains significantly higher than in the general population, in part because of the limited efficacy of available treatments and the associated toxicities. Therefore, novel targeted therapies are urgently needed to improve the outcomes of affected individuals. Erythropoietin (EPO), a kidney-produced hormone that promotes red blood cell production in response to hypoxia, has lately been shown to also possess non-erythropoietic properties, including immunomodulatory effects. In various models of autoimmune diseases, EPO limits cell apoptosis and favors cell clearance, while reducing proinflammatory cytokines and promoting the induction of regulatory T cells. Notably, EPO has been shown to reduce autoimmune response and decrease disease severity in mouse models of SLE. Herein, we review EPO's non-erythropoietic effects, with a special focus on immune modulating effects in SLE and its potential clinical utility.
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影响因子：
9.1
作者：
Chun, Hye-Young;Chung, Jae-Wook;Suh, Chang-Hee
通讯作者：
Suh, Chang-Hee
影响因子：
2.9
作者：
Agnello, D;Bigini, P;Ghezzi, P
通讯作者：
Ghezzi, P
DOI：
10.1186/2040-7378-1-4
发表时间：
2009-10-21
期刊：
Experimental & translational stroke medicine
影响因子：
--
作者：
Byts N;Sirén AL
通讯作者：
Sirén AL
影响因子：
5.4
作者：
Bunn, H. Franklin
通讯作者：
Bunn, H. Franklin
影响因子：
--
作者：
Cuzzocrea, Salvatore;Mazzon, Emanuela;Thiemermann, Christoph
通讯作者：
Thiemermann, Christoph