The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia?
The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia?
复制标题
大鼠在孔板设备中的探索性行为：头倾斜了有效的Neophilia量度吗？
DOI：
10.1016/j.beproc.2008.02.019
复制
发表时间：
2008-07
影响因子：
1.3
通讯作者：
Nemes, Christopher
中科院分区：
文献类型：
--
作者：
Brown, Gillian R.;Nemes, Christopher
实验室啮齿动物的探索行为在行为药理学的许多领域都很有趣。然而，如何最好地衡量啮齿动物的探索行为仍然是一个有争议的问题。许多无条件测试，例如开放场地，可能会将一般运动活动与探索混淆。孔板装置似乎避免了这种混淆，因为将头伸入地板上的孔中被认为是受试者对新奇事物（新奇癖）吸引力的有效衡量标准。本研究旨在通过比较成年雄性和雌性Lister头罩大鼠在孔板任务中的表现（a）重复训练和（b）当孔下不存在或存在新物体时，调查是否应将低头视为新恋物癖的有效衡量标准。结果表明，在重复暴露后，低头的次数最初减少，而在令人厌恶的中心区域花费的时间增加。当物体被放置在孔下面时，没有看到低头的变化。这些结果并不是衡量新事物的标准，而是支持这样的假设：低头代表一种逃避反应，随着受试者变得不那么害怕，这种反应会减弱。这些结果与之前反复暴露于其他新环境的研究进行了比较。
The exploratory behaviour of laboratory rodents is of interest within a number of areas of behavioural pharmacology. However, how best to measure exploratory behaviour in rodents remains a contentious issue. Many unconditioned tests, such as the open field, potentially confound general locomotor activity with exploration. The hole-board apparatus appears to avoid this confound, as head-dipping into holes in the floor is assumed to be a valid measure of the subject's attraction towards novelty (neophilia). This study aimed to investigate whether head-dipping should be considered a valid measure of neophilia by comparing performance of adult male and female Lister hooded rats on the hole-board task (a) over repeated sessions and (b) when novel objects were absent or present underneath the holes. The results show that head-dipping initially decreased across repeated exposures, while time spent in the aversive central area increased. No change in head-dipping was seen in response to objects being placed underneath the holes. Rather than being a measure of neophilia, these results support the hypothesis that head-dipping represents an escape response, which declines as the subject becomes less fearful. These results are compared with previous studies of repeated exposure to other novel environments.
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DOI：
10.1007/bf00421184
发表时间：
1975-01-01
期刊：
PSYCHOPHARMACOLOGIA
影响因子：
--
作者：
FILE, SE;WARDILL, AG
通讯作者：
WARDILL, AG
DOI：
10.1016/s0163-1047(86)80009-7
发表时间：
1986-01-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
BIRKE, LIA;SADLER, D
通讯作者：
SADLER, D
DOI：
10.1152/ajpregu.00424.2004
发表时间：
2004-11-01
影响因子：
2.8
作者：
Eckel, LA;Moore, SR
通讯作者：
Moore, SR
影响因子：
2.9
作者：
ABEL, EL
通讯作者：
ABEL, EL
影响因子：
2.9
作者：
Aguilar, R;Gil, L;Tobeña, A
通讯作者：
Tobeña, A