Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning.
Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning.
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DOI：
10.1111/j.1460-9568.2010.07153.x
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Janak PH
中科院分区：
文献类型：
--
作者：
Corbit LH;Janak PH
背侧纹状体（DS）与工具性学习有关，但其在刺激驱动行为获得中的作用尚不清楚。为了探索DS对反应-结果（R-O）和刺激-结果（S-O）联想学习的贡献，我们在受试者获得两个独特的新R-O对或两个独特的新S-O对的获取过程中，对DS的失活子区域（背外侧，前背内侧和后背内侧）进行了标记。为了测试特定的R-O或S-O关联是否在失活状态下习得，在无药物条件下对一个结果进行选择性饱腹感评估后对大鼠进行测试。在工具性任务中，对照组大鼠和背外侧纹状体（DLS）失活大鼠在学习过程中对获得贬值结果的杠杆的反应低于测试时对替代杠杆的反应，表明DLS对R-O关联的形成并不重要。与此相反，大鼠失活的内侧DS（DMS）（无论是前或后）在学习过程中的反应不加区分，这表明未能获得新的R-O协会。在巴甫洛夫任务中，控制和大鼠在学习过程中与前DMS失活预测贬值的结果在刺激的存在下，反应较少，而大鼠与DLS或后DMS失活在学习过程中同样的刺激，表明他们没有获得新的S-O协会。这些数据证实，DLS和前区DMS调解奖励相关的学习的不同方面，并建议后DMS可能调解两种形式的学习（R-O和S-O）的共同功能。最后，我们证明，S-O和R-O协会所需的选择性巴甫洛夫工具转移。
The dorsal striatum (DS) has been implicated in instrumental learning but its role in the acquisition of stimulus-driven behaviour is not clear. To explore the contribution of the DS to both response-outcome (R-O) and stimulus-outcome (S-O) associative learning, we pharmacologically inactivated subregions (dorsolateral, anterior dorsomedial and posterior dorsomedial) of the DS during acquisition sessions in which subjects acquired two unique, novel R-O pairs or two unique, novel S-O pairs. To test whether specific R-O or S-O associations were learned under inactivation, rats were tested following selective-satiety devaluation of one outcome under drug-free conditions. In the instrumental task, control rats and rats with dorsolateral striatum (DLS) inactivation during learning responded less on the lever that had earned the devalued outcome than on the alternative lever at test, indicating that the DLS is not critical for the formation of R-O associations. In contrast, rats with inactivation of the medial DS (DMS) (either anterior or posterior) during learning responded indiscriminately, suggesting failure to acquire the novel R-O associations. In the Pavlovian task, both controls and rats with anterior DMS inactivation during learning responded less in the presence of the stimulus predicting the devalued outcome, whereas rats with DLS or posterior DMS inactivation during learning responded equally to the stimuli, indicating that they had not acquired the novel S-O associations. These data confirm that the DLS and anterior region DMS mediate different aspects of reward-related learning, and suggest that the posterior DMS may mediate a function common to both forms of learning (R-O and S-O). Finally, we demonstrate that both S-O and R-O associations are required for selective Pavlovian-instrumental transfer.
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DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
Balleine, Bernard W.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A
影响因子：
5.3
作者：
Dwyer, Dominic M.;Killcross, Simon
通讯作者：
Killcross, Simon
DOI：
10.1037/0097-7403.16.1.40
发表时间：
1990-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
COLWILL, RM;RESCORLA, RA
通讯作者：
RESCORLA, RA
影响因子：
3.3
作者：
Featherstone, RE;McDonald, RJ
通讯作者：
McDonald, RJ