Visualization of erythrocyte stasis in the living human eye in health and disease.
Visualization of erythrocyte stasis in the living human eye in health and disease.
复制标题
DOI：
10.1016/j.isci.2022.105755
复制
发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
Saeedi, Osamah J.
中科院分区：
文献类型：
--
作者：
Li, Joanne;Wang, Dongyi;Pottenburgh, Jessica;Bower, Andrew J.;Asanad, Samuel;Lai, Eric W.;Simon, Caroline;Im, Lily;Huryn, Laryssa A.;Tao, Yang;Tam, Johnny;Saeedi, Osamah J.
在微循环中有报道称血细胞处于停滞状态，但其与健康和疾病的相关性尚未确定。在这项研究中，我们介绍了一种体内成像方法，揭示了一个以前未知的池的红细胞在停滞，位于毛细血管段的中枢神经系统，并存在于100%的受试者成像的存在。这些结果提供了一个关键的见解，即血细胞在穿过脉络膜微血管系统时会暂停，脉络膜微血管系统是一种血管结构，拥有体内任何组织的最高血流量。使用深度学习的临床实用性证明表明，青光眼中的红细胞停滞发生了改变，这表明脉络膜微血管的变化可能比以前认识到的更广泛。在单细胞水平监测脉络膜微血管的能力可能会导致新的策略，用于跟踪青光眼，年龄相关性黄斑变性和其他神经退行性疾病的微血管健康。红细胞处于停滞状态是活体人眼中的生理学稳健现象短暂停滞事件是脉络膜微血管系统的标志性特征停滞分布的变化揭示了青光眼中的脉络膜毛细血管损伤自适应光学可以有效地与红细胞介导的血管造影术结合健康科学;验光;眼像差测量
Blood cells trapped in stasis have been reported within the microcirculation, but their relevance to health and disease has not been established. In this study, we introduce an in vivo imaging approach that reveals the presence of a previously-unknown pool of erythrocytes in stasis, located within capillary segments of the CNS, and present in 100% of subjects imaged. These results provide a key insight that blood cells pause as they travel through the choroidal microvasculature, a vascular structure that boasts the highest blood flow of any tissue in the body. Demonstration of clinical utility using deep learning reveals that erythrocyte stasis is altered in glaucoma, indicating the possibility of more widespread changes in choroidal microvascular than previously realized. The ability to monitor the choroidal microvasculature at the single cell level may lead to novel strategies for tracking microvascular health in glaucoma, age-related macular degeneration, and other neurodegenerative diseases. Erythrocytes in stasis are physiologically robust phenomena in the living human eye Transient stasis events are a hallmark feature of the choroidal microvasculature Changes in the distribution of stasis reveals choriocapillaris damage in glaucoma Adaptive optics can be effectively combined with erythrocyte mediated angiography Health sciences; Optometry; Ocular aberrometry
登录
查看更多内容
影响因子：
3.1
作者：
Flower, Robert W.;Kling, Ronn
通讯作者：
Kling, Ronn
影响因子：
3.4
作者：
Bedggood, Phillip;Metha, Andrew
通讯作者：
Metha, Andrew
影响因子：
3.4
作者：
ALM, A;BILL, A
通讯作者：
BILL, A
影响因子：
4.2
作者：
Jo, Youn Hye;Shin, Joong Won;Kook, Michael S.
通讯作者：
Kook, Michael S.
DOI：
10.1364/josaa.20.002010
发表时间：
2003-11-01
影响因子：
1.9
作者：
Donnelly, WJ;Roorda, A
通讯作者：
Roorda, A