Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.
Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.
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DOI：
10.1007/s00702-008-0030-y
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发表时间：
2008-07
影响因子：
3.3
通讯作者：
Leenders, K. L.
中科院分区：
文献类型：
--
作者：
Bartels, A. L.;Willemsen, A. T. M.;Kortekaas, R.;de Jong, B. M.;de Vries, R.;de Klerk, O.;van Oostrom, J. C. H.;Portman, A.;Leenders, K. L.
P-糖蛋白（P-gp）转运系统的血脑屏障（BBB）外排功能降低可促进有毒化合物在脑中的蓄积，增加神经退行性病变（如帕金森病（PD））的风险。本研究使用[11 C]-维拉帕米PET在PD、PSP和MSA患者中研究了帕金森神经退行性综合征患者体内BBB P-gp功能。使用SPM研究了分布容积的区域差异，较高的摄取被解释为P-gp功能降低。与对照组相比，晚期PD患者和PSP患者额叶白色区的[11 C]-维拉帕米摄取增加;而原发PD患者中脑和额叶区的摄取较低。PSP和MSA患者基底节摄取增加。BBB P-gp功能下降似乎是神经退行性疾病的晚期事件，并可增强持续的神经退行性病变。原发性PD患者中脑和额叶区域的[11 C]-维拉帕米摄取较低可能表明P-gp功能的区域上调。
Decreased blood–brain barrier (BBB) efflux function of the P-glycoprotein (P-gp) transport system could facilitate the accumulation of toxic compounds in the brain, increasing the risk of neurodegenerative pathology such as Parkinson’s disease (PD). This study investigated in vivo BBB P-gp function in patients with parkinsonian neurodegenerative syndromes, using [11C]-verapamil PET in PD, PSP and MSA patients. Regional differences in distribution volume were studied using SPM with higher uptake interpreted as reduced P-gp function. Advanced PD patients and PSP patients had increased [11C]-verapamil uptake in frontal white matter regions compared to controls; while de novo PD patients showed lower uptake in midbrain and frontal regions. PSP and MSA patients had increased uptake in the basal ganglia. Decreased BBB P-gp function seems a late event in neurodegenerative disorders, and could enhance continuous neurodegeneration. Lower [11C]-verapamil uptake in midbrain and frontal regions of de novo PD patients could indicate a regional up-regulation of P-gp function.
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影响因子：
9.9
作者：
DAVIS, PH;GOLBE, LI;SCHOENBERG, BS
通讯作者：
SCHOENBERG, BS
影响因子：
9.9
作者：
Green, J;McDonald, WM;DeLong, MR
通讯作者：
DeLong, MR
影响因子：
3.4
作者：
Hennessy, M;Kelleher, D;Feely, J
通讯作者：
Feely, J
DOI：
10.1093/jnen/61.5.413
发表时间：
2002-05-01
影响因子：
3.2
作者：
Del Tredici, K;Rüb, U;Braak, H
通讯作者：
Braak, H
DOI：
10.1093/jnen/63.10.1038
发表时间：
2004-10-01
影响因子：
3.2
作者：
Langford, D;Grigorian, A;Masliah, E
通讯作者：
Masliah, E