The source of relaxin in pregnant Syrian hamsters.

The source of relaxin in pregnant Syrian hamsters.
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怀孕叙利亚仓鼠松弛素的来源。

DOI:
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发表时间:
1988
期刊:
影响因子:
4.8
通讯作者:
M. B. Anderson
M. B. Anderson
中科院分区:
医学2区
文献类型:
--
作者:
B. Steinetz;E. O'Byrne;L. Goldsmith;M. B. Anderson

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分别于妊娠第8、10、14天测定完整和去卵巢仓鼠(妊娠第8天)血清免疫反应性松弛素(IR)水平。在完整的仓鼠中,IR从妊娠第8天的3-4 ng/ml增加到妊娠第14天的20 ng/ml。卵巢切除术后第8天妊娠失败,第14天IR迅速下降至0.29 ng/ml。然而,当去卵巢仓鼠每天注射0.1微克17 -雌二醇和4毫克孕酮维持妊娠时,血清IR在妊娠第10天和第14天上升到与完整仓鼠相似的水平(即分别为15和20 ng/ml)。其他各组鼠于妊娠第11、14和15天取胎盘,均质后采用经典的豚鼠耻骨联合触诊生物测定法进行生物测定。第14天和第15天的胎盘匀浆中分别含有4和10微克猪松弛素/血清松弛素/g新鲜组织。胎盘,而不是卵巢,似乎是仓鼠怀孕期间荷尔蒙的来源。
Serum immunoreactive relaxin (IR) was measured on days 8, 10, and 14 of gestation in intact and ovariectomized (day 8 of pregnancy) hamsters. In intact hamsters, IR increased from 3-4 ng/ml on day 8 to 20 ng/ml by day 14 of pregnancy. After ovariectomy on day 8, pregnancy failed, and IR decreased rapidly to 0.29 ng/ml on day 14. However, when pregnancy was maintained in ovariectomized hamsters by daily injections of 0.1 microgram 17 beta-estradiol and 4 mg progesterone, serum IR rose to levels similar to those in intact hamsters on days 10 and 14 of pregnancy (i.e. 15 and 20 ng/ml, respectively). Placentas were obtained from other groups of hamsters on days 11, 14, and 15 of pregnancy and homogenized for bioassay by the classical guinea pig pubic symphysis palpation bioassay. Homogenates of placentas obtained on days 14 and 15 contained, respectively, 4 and 10 micrograms eq porcine relaxin/serum relaxin/g fresh tissue. The placenta, rather than the ovary, appears to be the source of during pregnancy in the hamster.
DOI: 10.1210/endo-116-3-1206
发表时间: 1985
期刊: Endocrinology
影响因子: 4.8
作者:
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通讯作者: Sherwood,OD
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恒河猴的松弛素分泌。
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发表时间: 1981
影响因子: 3.6
作者:
Weiss,G;Steinetz,BG;Dierschke,DJ;Fritz,G
通讯作者: Fritz,G
DOI: 10.1210/endo-116-3-1215
发表时间: 1985
期刊: Endocrinology
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作者:
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通讯作者: Sherwood,OD