The Ikaros family of zinc-finger proteins.
The Ikaros family of zinc-finger proteins.
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DOI：
10.1016/j.apsb.2016.06.002
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发表时间：
2016-11
影响因子：
14.5
通讯作者：
Lu, Duo
中科院分区：
文献类型：
--
作者：
Fan, Yingzhi;Lu, Duo
Ikaros代表一个锌指蛋白家族，对淋巴细胞发育和某些其他生理过程很重要。该家族成员的数量很大，选择性剪接从家族中的五个同源基因中的每一个产生各种额外的同种型。Ikaros蛋白的功能形式可能更加多样化，因为蛋白质-蛋白质相互作用在家族成员之间很容易建立。新出现的证据表明，靶向Ikaros蛋白在治疗应用中是可行和有效的，尽管Ikaros蛋白的确切作用在它们所涉及的复杂调控网络中仍然难以捉摸。在这篇综述中，我们收集现有的知识，以功能，调节途径，并试图通过比较家庭成员之间的活动和相互作用，以获得更好的理解，这个家庭的蛋白质的分子机制。Ikaros是一个大的锌指蛋白家族，对淋巴细胞发育和某些其他生理过程很重要。在这篇综述中，现有的知识，这个家族的蛋白质的功能，调节途径和分子机制的收集，以获得更好的理解，通过比较家庭成员之间的活动和相互作用。
Ikaros represents a zinc-finger protein family important for lymphocyte development and certain other physiological processes. The number of family members is large, with alternative splicing producing various additional isoforms from each of the five homologous genes in the family. The functional forms of Ikaros proteins could be even more diverse due to protein–protein interactions readily established between family members. Emerging evidence suggests that targeting Ikaros proteins is feasible and effective in therapeutic applications, although the exact roles of Ikaros proteins remain elusive within the intricate regulatory networks in which they are involved. In this review we collect existing knowledge as to the functions, regulatory pathways, and molecular mechanisms of this family of proteins in an attempt to gain a better understanding through the comparison of activities and interactions among family members. Ikaros is a large zinc-finger protein family important for lymphocyte development and certain other physiological processes. In this review, existing knowledge as to the functions, regulatory pathways, and molecular mechanisms of this family of proteins is collected in order to gain a better understanding through comparison of activities and interactions among family members.
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影响因子：
5
作者：
Fang, C-M;Roy, S.;Nielsen, E.;Paul, M.;Maul, R.;Paun, A.;Koentgen, F.;Raval, F. M.;Szomolanyi-Tsuda, E.;Pitha, P. M.
通讯作者：
Pitha, P. M.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
4.3
作者：
Dovat, Sinisa;Song, Chunhua;Payne, Kimberly J.;Li, Zhanjun
通讯作者：
Li, Zhanjun
影响因子：
5.3
作者：
Arco, PGD;Koipally, J;Georgopoulos, K
通讯作者：
Georgopoulos, K
影响因子：
20.3
作者：
Ferreiros-Vidal, Isabel;Carroll, Thomas;Merkenschlager, Matthias
通讯作者：
Merkenschlager, Matthias