Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction.
Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction.
复制标题
宫内血浆单核细胞趋化蛋白1浓度在宫内生长限制中。
DOI：
10.1155/2007/65032
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发表时间：
2007
影响因子：
4.6
通讯作者：
Malamitsi-Puchner, Ariadne
中科院分区：
文献类型：
--
作者：
Briana, Despina D.;Boutsikou, Maria;Baka, Stavroula;Papadopoulos, George;Gourgiotis, Dimitrios;Puchner, Karl Philipp;Hassiakos, Dimitrios;Malamitsi-Puchner, Ariadne
单核细胞趋化蛋白-1（MCP-1）在免疫应答、血管生成和妊娠结局中起重要作用。我们研究了40名母亲及其20名宫内生长受限（IUGR）和20名适合胎龄（阿加）胎儿和新生儿出生后第1天（N1）和第4天（N4）的血浆MCP-1浓度。母体和胎儿MCP-1浓度降低（分别为= 0.018），而IUGR组N1 MCP-1浓度升高（= 0.012）。在这两组中，胎儿MCP-1浓度低于N1和N4组（分别为= 0.045，= 0.012，对于阿加， 0.001（IUGR）。IUGR中母亲和胎儿MCP-1浓度的降低可能反映了滋养层细胞侵袭的失败，这表明MCP-1的下调可能参与了IUGR的发病机制。增加MCP-1浓度在IUGR新生儿和更高的出生后的所有婴儿可能是由于子宫外血管生成的逐渐启动，这可能是增强IUGR。
Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased ( and = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group ( = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones ( = .045, = .012, resp., for AGA, .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.
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影响因子：
1.8
作者：
Esplin, MS;Romero, R;Adashi, EY
通讯作者：
Adashi, EY
影响因子：
168.9
作者：
GARDOSI, J;CHANG, A;SYMONDS, EM
通讯作者：
SYMONDS, EM
影响因子：
3.6
作者：
Amu, S;Hahn-Zoric, M;Hanson, LÅ
通讯作者：
Hanson, LÅ
DOI：
10.1165/ajrcmb/9.3.300
发表时间：
1993-09-01
影响因子：
6.4
作者：
BRIELAND, JK;JONES, ML;FANTONE, JC
通讯作者：
FANTONE, JC
影响因子：
7.1
作者：
GARDOSI, J;MONGELLI, M;CHANG, A
通讯作者：
CHANG, A