Organ-on-Chip Devices Toward Applications in Drug Development and Screening
Organ-on-Chip Devices Toward Applications in Drug Development and Screening
复制标题
器官芯片设备在药物开发和筛选中的应用
DOI：
10.1115/1.4040272
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Liu, Yaling
中科院分区：
文献类型：
--
作者：
Uhl, Christopher;Shi, Wentao;Liu, Yaling
模拟真实的器官的活动、力学和生理反应的器官芯片（OOC）作为实现人造器官的必要途径，在过去的十年里引起了人们的广泛关注。随着三维细胞培养模型的成熟和微流体技术的发展，体外细胞培养的研究取得了重大进展。这篇综述文章提供了OOC微流体的全面概述和分类。具体而言，审查的重点是能够用于临床前药物筛选和开发的OOC系统。此外，审查强调了每个OOC系统的优点和缺点，以改善药物开发和筛选的目标。在整个审查中研究的各种OOC系统包括血管，肺，肝和肿瘤系统及其潜在的益处，每个系统都为高通量药物筛选带来了日益增长的挑战。在过去十年（2007-2018年）中，对已发表的OOC系统进行了审查，重点主要是每个器官系统的最新进展和改进。每个OOC系统都已经过审查，包括它能够模拟其生理对应物的程度和真实性，系统为药物开发和筛选的最终目标提供的信息程度，每个系统能够过渡到大规模高通量药物筛选的容易程度，以及对每个系统的进一步改进将有助于改善平台的功能，现实性，和吞吐能力。最后，总结了OOC的广阔领域似乎在不久的将来沿着与建议，在未来的努力应该集中在优化性能的OOC系统一般。
As a necessary pathway to man-made organs, organ-on-chips (OOC), which simulate the activities, mechanics, and physiological responses of real organs, have attracted plenty of attention over the past decade. As the maturity of three-dimensional (3D) cell-culture models and microfluidics advances, the study of OOCs has made significant progress. This review article provides a comprehensive overview and classification of OOC microfluidics. Specifically, the review focuses on OOC systems capable of being used in preclinical drug screening and development. Additionally, the review highlights the strengths and weaknesses of each OOC system toward the goal of improved drug development and screening. The various OOC systems investigated throughout the review include, blood vessel, lung, liver, and tumor systems and the potential benefits, which each provides to the growing challenge of high-throughput drug screening. Published OOC systems have been reviewed over the past decade (2007–2018) with focus given mainly to more recent advances and improvements within each organ system. Each OOC system has been reviewed on how closely and realistically it is able to mimic its physiological counterpart, the degree of information provided by the system toward the ultimate goal of drug development and screening, how easily each system would be able to transition to large scale high-throughput drug screening, and what further improvements to each system would help to improve the functionality, realistic nature of the platform, and throughput capacity. Finally, a summary is provided of where the broad field of OOCs appears to be headed in the near future along with suggestions on where future efforts should be focused for optimized performance of OOC systems in general.
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影响因子：
14
作者：
Hsiao, Amy Y.;Torisawa, Yu-suke;Tung, Yi-Chung;Sud, Sudha;Taichman, Russell S.;Pienta, Kenneth J.;Takayama, Shuichi
通讯作者：
Takayama, Shuichi
影响因子：
19
作者：
Huh, Dongeun;Hamilton, Geraldine A.;Ingber, Donald E.
通讯作者：
Ingber, Donald E.
影响因子：
6.2
作者：
Jedrych, Elzbieta;Pawlicka, Zuzanna;Brzozka, Zbigniew
通讯作者：
Brzozka, Zbigniew
影响因子：
6.1
作者：
Agarwal A;Goss JA;Cho A;McCain ML;Parker KK
通讯作者：
Parker KK
影响因子：
17.1
作者：
Agarwal P;Wang H;Sun M;Xu J;Zhao S;Liu Z;Gooch KJ;Zhao Y;Lu X;He X
通讯作者：
He X