WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny.
WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny.
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DOI：
10.1038/ki.2008.322
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发表时间：
2008-10
影响因子：
19.6
通讯作者：
Barasch, Jonathan
中科院分区：
文献类型：
--
作者：
Schmidt-Ott, Kai M.;Barasch, Jonathan
关键词：
WNT信号转导是胚胎发生和疾病的基本分子途径。肾单位的发育依赖于WNT信号传导。靠近集合管的肾单位上皮细胞由后肾间充质中的祖细胞发育而来。该过程涉及原上皮细胞聚集体的形成，转化为上皮细胞，以及肾单位的近端-远端图案化。来自WNT家族的两种配体，即Wnt 9 b和Wnt 4，是肾单位分化所必需的。最近的研究已经解决了这些WNT配体的下游靶点，并描绘了经典WNT信号通路的作用。该途径依赖于细胞内蛋白β-catenin和T细胞特异性转录因子/淋巴增强因子-1（TCF/Lef 1）家族的转录因子。选择性β-连环蛋白信号传导拮抗作用抑制后肾间充质祖细胞的分化，而强制激活触发向原上皮聚集体的阶段性进展。尽管如此，激活的途径是短暂的上皮分化和滴定的途径活动可能是中央的分化和形态发生的适当协调。我们回顾了目前关于WNT/β-catenin/TCF/Lef 1信号通路在肾上皮发育中的证据，并讨论了非经典WNT信号通路和WNT非依赖性事件的潜在意义。
WNT signaling is a fundamental molecular pathway in both embryogenesis and disease. Nephron development is dependent on WNT signaling. The nephron epithelia proximal to the collecting duct develop from progenitor cells in the metanephric mesenchyme. The process involves formation of proto-epithelial cell aggregates, conversion into epithelia, and proximal-distal patterning of the nephron. Two ligands from the WNT family, namely Wnt9b and Wnt4, are required for nephron differentiation. Recent studies have addressed the downstream targets of these WNT ligands and delineated the role of the canonical WNT signaling pathway. This pathway depends on the intracellular protein β-catenin and the T cell-specific transcription factor/lymphoid enhancer factor-1 (TCF/Lef1) family of transcription factors. Selective β-catenin signaling antagonism inhibits differentiation of metanephric mesenchymal progenitor cells, while forced activation triggers a stage progression towards proto-epithelial aggregates. Nonetheless, activation of the pathway is transient during epithelial differentiation and titration of pathway activity may be central for the proper coordination of differentiation and morphogenesis. We review current evidence on the WNT/β-catenin/TCF/Lef1 signaling pathway in kidney epithelial development and discuss the potential implication of non-canonical WNT signaling and WNT-independent events.
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影响因子：
11.8
作者：
Carroll, TJ;Park, JS;McMahon, AP
通讯作者：
McMahon, AP
DOI：
10.1007/s00467-007-0504-4
发表时间：
2007-11
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
Merkel CE;Karner CM;Carroll TJ
通讯作者：
Carroll TJ
DOI：
10.1083/jcb.200309096
发表时间：
2004-01-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ciani L;Krylova O;Smalley MJ;Dale TC;Salinas PC
通讯作者：
Salinas PC
影响因子：
30.8
作者：
Gerdes, Jantje M.;Liu, Yangfan;Katsanis, Nicholas
通讯作者：
Katsanis, Nicholas
影响因子：
2.7
作者：
Bridgewater, Darren;Cox, Brian;Rosenblum, Norman D.
通讯作者：
Rosenblum, Norman D.