Temperature-ramped (129)Xe spin-exchange optical pumping.
Temperature-ramped (129)Xe spin-exchange optical pumping.
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DOI：
10.1021/ac501537w
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发表时间：
2014-08-19
影响因子：
7.4
通讯作者：
Chekmenev, Eduard Y.
中科院分区：
文献类型：
--
作者：
Nikolaou, Panayiotis;Coffey, Aaron M.;Barlow, Michael J.;Rosen, Matthew S.;Goodson, Boyd M.;Chekmenev, Eduard Y.
我们描述了温度斜坡自旋交换光泵浦（TR-SEOP）在自动高通量批处理模式129 μ m超偏振器利用三个关键温度制度：（i）“热”-其中129 Ω超极化率最大，（ii）“暖”-其中129 Ω超极化接近1，和（iii）“冷”-其中将超极化129 Rb气体转移到具有低Rb含量（<5 ng/μ L剂量）的Tedlar袋中，该袋适合于人类成像应用。与间歇模式SEOP的常规方法不同，这里所有三个温度状态都可以在连续高功率（170 W）激光照射下操作，并且超极化129 Ω气体被递送而不需要低温收集步骤。与恒温极化速率相比，变温方法使SEOP速率增加了2倍以上（例如，给出了指数建立常数γSEOP的有效值（62.5 ± 3.7 × 10-3 min-1 vs 29.9 ± 1.2 × 10-3 min-1），同时获得了几乎相同的最大%P值（88.0 ± 0.8% vs 90.1% ± 0.8%，对于500 Torr（67 kPa）的磁共振室负载-对应于核磁共振/磁共振成像（NMR/MRI）在临床成像和HP 129产生3 T和4 mT的相关区域，增强分别为1.31 × 105和1.232 × 108），此外，周期间“死”时间也显著缩短。更高通量的TR-SEOP方法可以在不牺牲129 Ω超极化水平或自动化实验稳定性的情况下实现，使这种方法有利于提高临床环境中的总体129 Ω生产率。
We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”—where the 129Xe hyperpolarization rate is maximal, (ii) “warm”—where the 129Xe hyperpolarization approaches unity, and (iii) “cool”—where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content (<5 ng per ∼1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized 129Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10–3 min–1 vs 29.9 ± 1.2 × 10–3 min–1) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loading—corresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 105 and ∼2.32 × 108 at the relevant fields for clinical imaging and HP 129Xe production of 3 T and 4 mT, respectively); moreover, the intercycle “dead” time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of 129Xe hyperpolarization or the experimental stability for automation—making this approach beneficial for improving the overall 129Xe production rate in clinical settings.
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影响因子：
4.4
作者：
Mugler, John P.;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
影响因子：
15
作者：
Nikolaou P;Coffey AM;Walkup LL;Gust BM;LaPierre CD;Koehnemann E;Barlow MJ;Rosen MS;Goodson BM;Chekmenev EY
通讯作者：
Chekmenev EY
影响因子：
2.2
作者：
Nikolaou, Panayiotis;Whiting, Nicholas;Barlow, Michael J.
通讯作者：
Barlow, Michael J.
影响因子：
2.9
作者：
Nelson, IA;Walker, TG
通讯作者：
Walker, TG
影响因子：
19.7
作者：
Driehuys, Bastiaan;Martinez-Jimenez, Santiago;McAdams, H. Page
通讯作者：
McAdams, H. Page