A 3D-printed high power nuclear spin polarizer.
A 3D-printed high power nuclear spin polarizer.
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DOI：
10.1021/ja412093d
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发表时间：
2014-01-29
影响因子：
15
通讯作者：
Chekmenev EY
中科院分区：
文献类型：
--
作者：
Nikolaou P;Coffey AM;Walkup LL;Gust BM;LaPierre CD;Koehnemann E;Barlow MJ;Rosen MS;Goodson BM;Chekmenev EY
高温塑料三维打印用于实现自旋交换光泵浦（SEOP）和氙-129气体的超极化。3D打印结构的使用增加了以下关键部件与可变温度SEOP探头集成的简单性：(i) 84 kHz的原位核磁共振电路（129Xe和1H核自旋的Larmor频率），(ii) <0.3 nm的200 W激光源，（iii）原位高分辨率近红外光谱，（iv）热电温度控制，(v)反向反射光学，（vi）光机械校准系统。3D打印赋予的快速原型大大减少了生产时间和费用，同时允许“现成”组件的再现性和集成，并实现按需打印的概念。本文演示了该SEOP装置的实用性，在0.5 L光泵浦电池中获得了接近统一的129Xe偏振值，在1000托的氙气分压下，偏振值为~74±7%，这是在如此高的氙密度下的记录值。129Xe在1000 Torr下的极化指数建立速率[（3.63±0.15）× 10−2 min−1]和129Xe在胞内的自旋-晶格弛豫时间（T1 = 2.19±0.06 h）与129Xe和Rb的气相极化比（PRb ~ 96%）非常吻合。超偏振增强的129Xe气体成像通过一个球形幻像进行演示，该幻像由偏振器自动传输气体。综上所述，这些结果支持了广泛的化学、生物化学、材料科学和生物医学应用的发展。
Three-dimensional printing with high-temperature plastic is used to enable spin exchange optical pumping (SEOP) and hyperpolarization of xenon-129 gas. The use of 3D printed structures increases the simplicity of integration of the following key components with a variable temperature SEOP probe: (i) in situ NMR circuit operating at 84 kHz (Larmor frequencies of 129Xe and 1H nuclear spins), (ii) <0.3 nm narrowed 200 W laser source, (iii) in situ high-resolution near-IR spectroscopy, (iv) thermoelectric temperature control, (v) retroreflection optics, and (vi) optomechanical alignment system. The rapid prototyping endowed by 3D printing dramatically reduces production time and expenses while allowing reproducibility and integration of “off-the-shelf” components and enables the concept of printing on demand. The utility of this SEOP setup is demonstrated here to obtain near-unity 129Xe polarization values in a 0.5 L optical pumping cell, including ~74 ± 7% at 1000 Torr xenon partial pressure, a record value at such high Xe density. Values for the 129Xe polarization exponential build-up rate [(3.63 ± 0.15) × 10−2 min−1] and in-cell 129Xe spin−lattice relaxation time (T1 = 2.19 ± 0.06 h) for 1000 Torr Xe were in excellent agreement with the ratio of the gas-phase polarizations for 129Xe and Rb (PRb ~ 96%). Hyperpolarization-enhanced 129Xe gas imaging was demonstrated with a spherical phantom following automated gas transfer from the polarizer. Taken together, these results support the development of a wide range of chemical, biochemical, material science, and biomedical applications.
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影响因子：
4.4
作者：
Mugler, John P.;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
影响因子：
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作者：
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作者：
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通讯作者：
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