Functional contributions and interactions between the human hippocampus and subregions of the striatum during arbitrary associative learning and memory.
Functional contributions and interactions between the human hippocampus and subregions of the striatum during arbitrary associative learning and memory.
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DOI：
10.1002/hipo.22411
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发表时间：
2015-08
期刊：
影响因子：
3.5
通讯作者：
Stark, Craig E. L.
中科院分区：
文献类型：
--
作者：
Mattfeld, Aaron T.;Stark, Craig E. L.
海马体和纹状体被认为在学习和记忆中具有不同的功能作用。目前尚不清楚他们的贡献在什么实验条件下不同或趋同，以及他们在学习过程中相互作用的程度。为了评估人类海马体和纹状体的功能贡献以及之间的相互作用，本研究使用了高分辨率功能磁共振成像（fMRI）和条件视觉运动联想学习任务的变体，该任务要么对任意联想学习（实验1）或刺激反应学习（实验2）进行征税。在第一个实验中，我们观察到海马体和前尾状核活动的变化，这反映了两个区域之间的差异，符合不同的计算原理。在第二个实验中，我们观察到壳核的活动反映了学习任意条件视觉运动关联期间的内容特定表征。在这两项实验中，海马体和腹侧纹状体在学习新的任意关联期间表现出动态功能耦合，但在使用不优先对一个系统施加相对于另一个系统的任务的控制变体检索充分学习的任意关联的过程中表现出动态功能耦合。这些发现表明，海马体和背侧纹状体的亚区域对任意关联的学习都有独特的贡献，而海马体和腹侧纹状体在学习过程中相互作用。
The hippocampus and striatum are thought to have different functional roles in learning and memory. It is unknown under what experimental conditions their contributions are dissimilar or converge, and the extent to which they interact over the course of learning. In order to evaluate both the functional contributions of as well as the interactions between the human hippocampus and striatum, the present study used high-resolution functional magnetic resonance imaging (fMRI) and variations of a conditional visuomotor associative learning task that either taxed arbitrary associative learning (Experiment 1) or stimulus-response learning (Experiment 2). In the first experiment we observed changes in activity in the hippocampus and anterior caudate that reflect differences between the two regions consistent with distinct computational principles. In the second experiment we observed activity in the putamen that reflected content specific representations during the learning of arbitrary conditional visuomotor associations. In both experiments the hippocampus and ventral striatum demonstrated dynamic functional coupling during the learning of new arbitrary associations, but not during retrieval of well-learned arbitrary associations using control variants of the tasks that did not preferentially tax one system versus the other. These findings suggest that both the hippocampus and subregions of the dorsal striatum contribute uniquely to the learning of arbitrary associations while the hippocampus and ventral striatum interact over the course of learning.
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影响因子：
5.3
作者：
Law, JR;Flanery, MA;Stark, CEL
通讯作者：
Stark, CEL
DOI：
10.1080/14640748308400912
发表时间：
1983-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
DICKINSON, A;NICHOLAS, DJ;ADAMS, CD
通讯作者：
ADAMS, CD
影响因子：
3.7
作者：
Mattfeld, Aaron T.;Stark, Craig E. L.
通讯作者：
Stark, Craig E. L.
影响因子：
15.9
作者：
Goto, Yukiori;Grace, Anthony A.
通讯作者：
Grace, Anthony A.
影响因子：
2
作者：
Lacy, Joyce W.;Yassa, Michael A.;Stark, Craig E. L.
通讯作者：
Stark, Craig E. L.