Limbic and cortical information processing in the nucleus accumbens.

Limbic and cortical information processing in the nucleus accumbens.
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DOI:
10.1016/j.tins.2008.08.002
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发表时间:
2008-11
影响因子:
15.9
通讯作者:
Grace, Anthony A.
Grace, Anthony A.
中科院分区:
医学1区
文献类型:
--
作者:
Goto, Yukiori;Grace, Anthony A.

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伏隔核通过整合来自边缘结构和前额皮质的信息来调节目标导向的行为。在这里,我们回顾了最近的研究,试图从目标导向行为的调节方面提供伏隔核信息处理控制的综合观点,以及这些功能的破坏如何可能成为吸毒成瘾和其他精神疾病的病理状态的基础。我们提出了一个模型,可以解释几项调查伏隔核边缘系统相互作用及其多巴胺调节的研究结果,并为这些可能与主要精神疾病的病理生理学如何相关提供可检验的假设。
The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.
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