The developmental hourglass model and recapitulation: An attempt to integrate the two models.
The developmental hourglass model and recapitulation: An attempt to integrate the two models.
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DOI：
10.1002/jez.b.23027
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发表时间：
2022-01
影响因子：
2.2
通讯作者：
Irie, Naoki
中科院分区：
文献类型：
--
作者：
Uesaka, Masahiro;Kuratani, Shigeru;Irie, Naoki
关键词：
重演是一个假设的概念，假设动物的胚胎发生与其自身的系统发育历史平行，从更原始的特征顺序发展到更衍生的特征。这一概念预测，各种动物的最早发育阶段应该代表进化上最保守的模式。另一方面，最近基于转录组的研究报道，胚胎中期，器官发生期显示出最高水平的保守性（发育沙漏模型）。然而，这并不排除在胚胎中期后仍能检测到重演的可能性。根据这一点，重演样形态特征在发育后期丰富。此外，我们最近的基于染色质可及性的研究为脊椎动物胚胎发生中晚期的重演提供了分子证据，因为新进化的基因调控元件往往在胚胎晚期被激活。在这篇综述中，我们重新审视了重演假说，以及最近支持发育沙漏模型的基于分子的研究。我们认为，重演假说并不完全矛盾的发展沙漏模型，这两个甚至可能共存于脊椎动物的胚胎后期阶段。最后，我们回顾了可能的机制的重演模式的染色质可及性与沙漏样的进化保守在脊椎动物胚胎发生。发育沙漏模型表明，基因表达谱和再现模式的染色质可及性可能相互吻合，在以后的脊椎动物胚胎发生。确切的进化机制在很大程度上仍不清楚。然而，一种可能性是，基因组区域的染色质可及性的重演模式（右图）是基因表达谱多样化（左图）以及胚胎发生后期某些形态性状所表现出的重演模式的基础。 据报道，在胚胎发育中期至晚期，染色质可及性的重演模式。所观察到的重演模式和发展沙漏模型可能共存。讨论了胚胎进化趋势背后可能的进化机制。
Recapitulation is a hypothetical concept that assumes embryogenesis of an animal parallels its own phylogenetic history, sequentially developing from more ancestral features to more derived ones. This concept predicts that the earliest developmental stage of various animals should represent the most evolutionarily conserved patterns. Recent transcriptome‐based studies, on the other hand, have reported that mid‐embryonic, organogenetic periods show the highest level of conservation (the developmental hourglass model). This, however, does not rule out the possibility that recapitulation would still be detected after the mid‐embryonic period. In accordance with this, recapitulation‐like morphological features are enriched in late developmental stages. Moreover, our recent chromatin accessibility‐based study provided molecular evidence for recapitulation in the mid‐to‐late embryogenesis of vertebrates, as newly evolved gene regulatory elements tended to be activated at late embryonic stages. In this review, we revisit the recapitulation hypothesis, together with recent molecular‐based studies that support the developmental hourglass model. We contend that the recapitulation hypothesis does not entirely contradict the developmental hourglass model and that these two may even coexist in later embryonic stages of vertebrates. Finally, we review possible mechanisms underlying the recapitulation pattern of chromatin accessibility together with the hourglass‐like evolutionary conservation in vertebrate embryogenesis. The developmental hourglass model showing that gene expression profiles and the recapitulation pattern of chromatin accessibility may coincide with each other in later vertebrate embryogenesis. The exact evolutionary mechanism remains largely unclear. However, one possibility would be that the recapitulation pattern in chromatin accessibility of genomic regions (right panel) underlies the diversification of gene expression profiles (left panel) as well as the recapitulation pattern exhibited by some morphological traits during later embryogenesis. Recapitulation pattern has been reported for chromatin accessibility during the mid‐to‐late embryogenesis. The observed recapitulation pattern and the developmental hourglass model may coexist. The possible evolutionary mechanisms underlying tendencies of embryonic evolution were discussed.
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DOI：
10.1002/jez.b.21033
发表时间：
2005-03-15
影响因子：
2.2
作者：
Hazkani-Covo, E;Wool, D;Graur, D
通讯作者：
Graur, D
两个层面的进化：基因和形态。
影响因子：
9.8
作者：
Carroll, SB
通讯作者：
Carroll, SB
DOI：
10.1126/science.aau0730
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cao J;Cusanovich DA;Ramani V;Aghamirzaie D;Pliner HA;Hill AJ;Daza RM;McFaline-Figueroa JL;Packer JS;Christiansen L;Steemers FJ;Adey AC;Trapnell C;Shendure J
通讯作者：
Shendure J
影响因子：
64.8
作者：
Cohn, MJ;Tickle, C
通讯作者：
Tickle, C
影响因子：
4.6
作者：
Gildor, Tsvia;Cary, Gregory A.;De-Leon, Smadar Ben-Tabou
通讯作者：
De-Leon, Smadar Ben-Tabou