Childhood urbanicity interacts with polygenic risk for depression to affect stress-related medial prefrontal function.
Childhood urbanicity interacts with polygenic risk for depression to affect stress-related medial prefrontal function.
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DOI：
10.1038/s41398-021-01650-x
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发表时间：
2021-10-12
影响因子：
6.8
通讯作者：
Tan HY
中科院分区：
文献类型：
--
作者：
Zhang X;Yan H;Yu H;Zhao X;Shah S;Dong Z;Yang G;Zhang X;Muse T;Li J;Jiang S;Liao J;Zhang Y;Chen Q;Weinberger DR;Yue W;Zhang D;Tan HY
城市化在全球范围内不断增加，与压力和心理健康风险增加有关，包括抑郁症。然而，目前还不清楚，特别是在大脑功能水平上，城市化，社会威胁压力源和精神病风险可能是如何联系在一起的。在这里，我们的目标是定义的结构和功能的MRI神经相关的社会压力，儿童的城市化，和他们的推定的机械相关性抑郁症的风险，在行为特征和遗传学。我们研究了一个健康的成年人样本，他们有着不同的城市和农村童年。我们研究了儿童期城市化对大脑结构的影响，如MRI所示，以及其与抑郁风险的功能相关性，通过城市化与特质焦虑抑郁之间的相互作用，以及城市化与抑郁的多基因风险之间的相互作用，在压力相关的内侧前额叶皮层（mPFC）参与。不同的农村和城市的童年受试者在成年后的社会经济地位相似，遗传同质。城市儿童与MRI显示的mPFC灰质体积相对减少有关。社会地位威胁下的MPFC参与与较高的特质焦虑抑郁症的主题与城市的童年，但不是在他们的农村同行，暗示夸大的生理反应与城市的威胁背景下，与抑郁症的行为风险。与压力相关的mPFC参与也与抑郁症的多基因风险相互作用，显著预测城市而非农村儿童个体的差异mPFC反应。因此，发展城市化，似乎与抑郁症的遗传和行为风险的mPFC神经反应的威胁背景。
Urbanization is increasing globally, and is associated with stress and increased mental health risks, including for depression. However, it remains unclear, especially at the level of brain function, how urbanicity, social threat stressors, and psychiatric risk may be linked. Here, we aim to define the structural and functional MRI neural correlates of social stress, childhood urbanicity, and their putative mechanistic relevance to depressive illness risk, in terms of behavioral traits and genetics. We studied a sample of healthy adults with divergent urban and rural childhoods. We examined childhood urbanicity effects on brain structure as suggested by MRI, and its functional relevance to depression risk, through interactions between urbanicity and trait anxiety-depression, as well as between urbanicity and polygenic risk for depression, during stress-related medial prefrontal cortex (mPFC) engagement. Subjects with divergent rural and urban childhoods were similar in adult socioeconomic status and were genetically homogeneous. Urban childhood was associated with relatively reduced mPFC gray matter volumes as suggested by MRI. MPFC engagement under social status threat correlated with the higher trait anxiety-depression in subjects with urban childhoods, but not in their rural counterparts, implicating an exaggerated physiological response to the threat context with urbanicity, in association with behavioral risk for depression. Stress-associated mPFC engagement also interacted with polygenic risk for depression, significantly predicting a differential mPFC response in individuals with urban but not rural childhoods. Developmental urbanicity, therefore, appears to interact with genetic and behavioral risk for depression on the mPFC neural response to a threat context.
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影响因子：
10.6
作者：
Ansell, Emily B.;Rando, Kenneth;Tuit, Keri;Guarnaccia, Joseph;Sinha, Rajita
通讯作者：
Sinha, Rajita
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium
影响因子：
4.8
作者：
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Sareen, Jitender
影响因子：
5.3
作者：
Amat, Jose;Paul, Evan;Maier, Steven F.
通讯作者：
Maier, Steven F.
DOI：
10.1073/pnas.071043098
发表时间：
2001-03-27
影响因子：
11.1
作者：
Gusnard, DA;Akbudak, E;Raichle, ME
通讯作者：
Raichle, ME