Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions.
Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions.
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DOI：
10.1016/j.biopsych.2011.11.022
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发表时间：
2012-07-01
影响因子：
10.6
通讯作者：
Sinha, Rajita
中科院分区：
文献类型：
--
作者：
Ansell, Emily B.;Rando, Kenneth;Tuit, Keri;Guarnaccia, Joseph;Sinha, Rajita
关键词：
累积的逆境和压力与精神疾病的风险有关。虽然基础科学研究表明，反复和慢性压力对前额叶和边缘神经元的影响，人类研究的累积压力和对大脑形态的影响是罕见的。因此，我们评估了累积逆境是否与灰质体积的差异有关，特别是在社区样本中调节情绪，自我控制和自上而下处理的区域。103名健康的社区参与者，年龄在18至48岁之间，68%为男性，完成了累积逆境和结构磁共振成像协议的访谈评估。进行全脑基于体素的形态测定分析，调整年龄、性别和颅内总体积。累积的逆境与内侧前额叶皮质（PFC）、岛叶皮质和膝下前扣带区的体积较小相关（家庭误差校正，p <0.001）。最近的压力性生活事件与两个集群中的较小体积相关：内侧PFC和右侧PFC。生活创伤与内侧PFC、前扣带回和膝下区的体积较小相关。更大的主观慢性压力和更大的累积生活事件的相互作用与眶额皮质、颞叶、前扣带和膝下扣带区的体积较小相关。目前的研究结果表明，不良生活事件的累积暴露增加与参与压力，情绪和奖励调节以及冲动控制的关键前额叶和边缘系统区域的灰质体积较小有关。在社区参与者中发现的这些差异可能有助于介导抑郁症，成瘾和其他与压力相关的精神病理学的脆弱性。
Cumulative adversity and stress are associated with risk of psychiatric disorders. While basic science studies show repeated and chronic stress effects on prefrontal and limbic neurons, human studies examining cumulative stress and effects on brain morphology are rare. Thus, we assessed whether cumulative adversity is associated with differences in gray matter volume, particularly in regions regulating emotion, self-control, and top-down processing in a community sample. One hundred three healthy community participants, aged 18 to 48 and 68% male, completed interview assessment of cumulative adversity and a structural magnetic resonance imaging protocol. Whole-brain voxel-based-morphometry analysis was performed adjusting for age, gender, and total intracranial volume. Cumulative adversity was associated with smaller volume in medial prefrontal cortex (PFC), insular cortex, and subgenual anterior cingulate regions (familywise error corrected, p <.001). Recent stressful life events were associated with smaller volume in two clusters: the medial PFC and the right insula. Life trauma was associated with smaller volume in the medial PFC, anterior cingulate, and subgenual regions. The interaction of greater subjective chronic stress and greater cumulative life events was associated with smaller volume in the orbitofrontal cortex, insula, and anterior and subgenual cingulate regions. Current results demonstrate that increasing cumulative exposure to adverse life events is associated with smaller gray matter volume in key prefrontal and limbic regions involved in stress, emotion and reward regulation, and impulse control. These differences found in community participants may serve to mediate vulnerability to depression, addiction, and other stress-related psychopathology.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
5.7
作者：
Ganzel, Barbara L.;Kim, Pilyoung;Temple, Elise
通讯作者：
Temple, Elise
影响因子：
10.6
作者：
Duman, RS;Malberg, J;D'Sa, C
通讯作者：
D'Sa, C
影响因子：
10.6
作者：
Franklin, TR;Acton, PD;Childress, AR
通讯作者：
Childress, AR
DOI：
10.1097/00000374-200204000-00017
发表时间：
2002-04-01
影响因子：
3.2
作者：
Fein, G;Di Sclafani, V;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ