A Particle Model for Prediction of Cement Infiltration of Cancellous Bone in Osteoporotic Bone Augmentation.
A Particle Model for Prediction of Cement Infiltration of Cancellous Bone in Osteoporotic Bone Augmentation.
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DOI：
10.1371/journal.pone.0067958
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Armand M
中科院分区：
文献类型：
--
作者：
Basafa E;Murphy RJ;Kutzer MD;Otake Y;Armand M
股骨成形术是骨质疏松性髋部骨折的一种潜在预防性治疗方法。它通过注射聚甲基丙烯酸甲酯（PMMA）骨水泥来增强股骨的力学性能。然而，为了降低相关风险并使治疗效果最大化，该手术需要精心规划和实施。规划系统的一个重要部分是预测骨水泥在松质骨多孔介质中的渗透情况。我们使用光滑粒子流体动力学（SPH）方法对多孔介质内PMMA的流动进行建模。我们修改了SPH的标准公式，以纳入与骨水泥相关的极高粘度。模拟了流体通过各向同性多孔介质的达西渗流，并将结果与文献报道的结果进行了比较。进一步的验证包括在多孔泡沫块（骨质疏松性松质骨替代物）内注射PMMA骨水泥，并使用我们提出的SPH模型模拟注射过程。在比较模拟和实际的骨水泥形状时，达到了毫米级的精度。此外，在扩散距离（R² = 0.86）和归一化压力（R² = 0.90）的模拟数据和实验数据之间发现了很强的相关性。结果表明，所提出的模型适用于骨质疏松性股骨增强规划框架。
Femoroplasty is a potential preventive treatment for osteoporotic hip fractures. It involves augmenting mechanical properties of the femur by injecting Polymethylmethacrylate (PMMA) bone cement. To reduce the risks involved and maximize the outcome, however, the procedure needs to be carefully planned and executed. An important part of the planning system is predicting infiltration of cement into the porous medium of cancellous bone. We used the method of Smoothed Particle Hydrodynamics (SPH) to model the flow of PMMA inside porous media. We modified the standard formulation of SPH to incorporate the extreme viscosities associated with bone cement. Darcy creeping flow of fluids through isotropic porous media was simulated and the results were compared with those reported in the literature. Further validation involved injecting PMMA cement inside porous foam blocks — osteoporotic cancellous bone surrogates — and simulating the injections using our proposed SPH model. Millimeter accuracy was obtained in comparing the simulated and actual cement shapes. Also, strong correlations were found between the simulated and the experimental data of spreading distance (R2 = 0.86) and normalized pressure (R2 = 0.90). Results suggest that the proposed model is suitable for use in an osteoporotic femoral augmentation planning framework.
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影响因子：
2.2
作者：
Baroud, G;Wu, JZ;Steffen, T
通讯作者：
Steffen, T
影响因子：
2.2
作者：
Basafa, Ehsan;Armiger, Robert S.;Armand, Mehran
通讯作者：
Armand, Mehran
影响因子：
3.8
作者：
Dragomir-Daescu D;Op Den Buijs J;McEligot S;Dai Y;Entwistle RC;Salas C;Melton LJ 3rd;Bennet KE;Khosla S;Amin S
通讯作者：
Amin S
影响因子：
14
作者：
Bohner, M;Gasser, B;Heini, P
通讯作者：
Heini, P
DOI：
10.1002/nag.898
发表时间：
2011-03-01
影响因子：
4
作者：
Holmes, David W.;Williams, John R.;Tilke, Peter
通讯作者：
Tilke, Peter