Pyroptosis in the Initiation and Progression of Atherosclerosis.
Pyroptosis in the Initiation and Progression of Atherosclerosis.
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DOI：
10.3389/fphar.2021.652963
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发表时间：
2021
影响因子：
5.6
通讯作者：
Bao Z
中科院分区：
文献类型：
--
作者：
Qian Z;Zhao Y;Wan C;Deng Y;Zhuang Y;Xu Y;Zhu Y;Lu S;Bao Z
细胞焦亡是一种新发现的程序性细胞死亡形式，其特征是细胞肿胀、质膜上出现大气泡和细胞裂解。该死亡途径由gasdermin D (GSDMD) 的孔形成介导，GSDMD 被人caspase-1/caspase-4/caspase-5（或小鼠caspase-1/caspase11）激活，随后释放细胞内容物和促炎细胞因子。焦亡最初被发现是一种先天免疫效应机制，有助于宿主防御病原微生物，随后的研究表明焦亡在炎症免疫疾病和肿瘤抵抗中也发挥着重要作用。最近的研究还表明焦亡参与动脉粥样硬化的发生、进展和并发症。在这里，我们通过关注三种重要的参与细胞：EC、巨噬细胞和 SMC，概述焦亡在动脉粥样硬化中的作用。此外，我们还总结了通过影响细胞焦亡来调节动脉粥样硬化进展的药物和刺激物。
Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This death pathway is mediated by the pore formation of gasdermin D (GSDMD), which is activated by human caspase-1/caspase-4/caspase-5 (or mouse caspase-1/caspase11), and followed with the releasing of both cell contents and proinflammatory cytokines. Pyroptosis was initially found to function as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, and subsequent studies revealed that pyroptosis also plays an eventful role in inflammatory immune diseases and tumor resistance. Recent studies have also shown that pyroptosis is involved in the initiation, the progression and complications of atherosclerosis. Here, we provide an overview of the role of pyroptosis in atherosclerosis by focusing on three important participating cells: ECs, macrophages, and SMCs. In addition, we also summarized drugs and stimuli that regulate the progression of atherosclerosis by influencing cell pyroptosis.
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DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA
影响因子：
20.1
作者：
Gimbrone MA Jr;García-Cardeña G
通讯作者：
García-Cardeña G
影响因子：
64.8
作者：
Ding, Jingjin;Wang, Kun;Shao, Feng
通讯作者：
Shao, Feng
影响因子：
20.1
作者：
Bentzon, Jacob Fog;Otsuka, Fumiyuki;Falk, Erling
通讯作者：
Falk, Erling