Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age.
Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age.
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DOI：
10.1016/j.scitotenv.2018.09.362
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发表时间：
2019-02-10
期刊：
影响因子：
--
通讯作者：
Mendola P
中科院分区：
文献类型：
--
作者：
Nobles CJ;Grantz KL;Liu D;Williams A;Ouidir M;Seeni I;Sherman S;Mendola P
环境空气污染可能通过几种机制影响胎儿生长受限（FGR）。然而，先前对空气污染和小于胎龄儿（SGA）的研究（FGR的常见代表）报告了不一致的结果。我们在尤妮斯·肯尼迪·施莱佛国家儿童健康和人类发展研究所（NICHD）的连续妊娠研究（2002-2010）中评估了空气污染与医生诊断的FGR和基于人群的SGA的关系。在50，005名妇女（112，203例单胎分娩）中，FGR从医疗记录和ICD-9编码中获得，SGA根据出生体重<第10百分位数，<第5百分位数和<第3百分位数的人口标准确定。社区多尺度空气质量模型估计了整个怀孕期间，怀孕前3个月以及第一，第二和第三个三个月的七种标准污染物的环境水平。广义估计方程与强大的标准误差占怀孕的相互依赖性内的参与者。模型根据母亲年龄、种族/民族、孕前体重指数、吸烟、饮酒、产次、保险、婚姻状况、哮喘和体温进行调整。1.5%的婴儿被诊断为FGR，6.7%的婴儿小于第10百分位数，2.7%小于第5百分位数，1.5%小于第3百分位数。SO2，NO2和PM10的正相关和负相关的O3与FGR观察整个孕前和怀孕。例如，整个妊娠期SO2的四分位数增加与FGR风险增加16%（95% CI 8%，25%）相关，NO2增加17%（95% CI 9%，26%），PM10增加12%（95% CI 6%，19%）。与SGA的关系不太清楚。长期暴露于空气污染可能与FGR有关，但在这个低风险人群中与SGA无关。
Ambient air pollution may affect fetal growth restriction (FGR) through several mechanisms. However, prior studies of air pollution and small-for-gestational age (SGA), a common proxy for FGR, have reported inconsistent findings. We assessed air pollution in relation to physician-diagnosed FGR and population-based SGA in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Consecutive Pregnancy Study (2002-2010). Among 50,005 women (112,203 singleton births), FGR was captured from medical records and ICD-9 codes, and SGA determined by population standards for birthweight <10th, <5th and <3rd percentile. Community Multiscale Air Quality models estimated ambient levels of seven criteria pollutants for whole pregnancy, 3-months preconception, and 1st, 2nd and 3rd trimesters. Generalized estimating equations with robust standard errors accounted for interdependency of pregnancies within participant. Models adjusted for maternal age, race/ethnicity, pre-pregnancy body mass index, smoking, alcohol, parity, insurance, marital status, asthma and temperature. FGR was diagnosed in 1.5% of infants, and 6.7% were <10th, 2.7% <5th and 1.5% <3rd percentile for SGA. Positive associations of SO2, NO2 and PM10 and negative associations of O3 with FGR were observed throughout preconception and pregnancy. For example, an interquartile increase in whole pregnancy SO2 was associated with 16% (95% CI 8%, 25%) increased FGR risk, 17% for NO2 (95% CI 9%, 26%) and 12% for PM10 (95% CI 6%, 19%). Associations with SGA were less clear. Chronic exposure to air pollution may be associated with FGR but not SGA in this low-risk population.
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影响因子：
10.4
作者：
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影响因子：
8.3
作者：
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通讯作者：
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影响因子：
10.4
作者：
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通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
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影响因子：
9.8
作者：
McConnell, Rob;Berhane, Kiros;Peters, John M.
通讯作者：
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