Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain.
Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain.
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在西班牙一个多中心队列中，怀孕期间的住宅暴露于怀孕期间的室外空气污染和人体测量指标。
DOI：
10.1289/ehp.1002918
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发表时间：
2011-09
影响因子：
10.4
通讯作者：
Iñiguez C
中科院分区：
文献类型：
--
作者：
Estarlich M;Ballester F;Aguilera I;Fernández-Somoano A;Lertxundi A;Llop S;Freire C;Tardón A;Basterrechea M;Sunyer J;Iñiguez C
背景：越来越多的研究表明，产前暴露在空气污染中可能对胎儿发育有害。我们在西班牙儿童健康与环境(INMA)母婴队列研究的四个领域评估了怀孕期间暴露于空气污染与出生时人体测量指标之间的关联。方法：对每名女性(n=2,337)在每个三个月和整个怀孕期间暴露于环境中的二氧化氮(NO2)和苯的情况进行评估。结果包括出生体重、身长和头围。通过控制潜在混杂因素的线性回归模型，评估了住宅室外空气污染暴露与出生结局之间的关系。我们还对怀孕期间在家呆更多时间的女性子组进行了敏感性分析。最后，我们结合Meta分析技术进行了分析。结果：在联合分析中，孕期NO2暴露增加10微克/立方米与出生身长减少-0.9 mm[95%可信区间(CI)-1.8至-0.1 mm]相关。对于每天在家中≥15小时的女性来说，这种关联性更强(-0.16 mm；95%CI，-0.27至-0.04)。对于这同一组妇女，出生体重减少22g与中期NO2暴露每增加10微克/立方米相关(95%CI，-45.3%至1.9)。我们没有观察到苯水平和出生结局之间的显著关系。结论：接触NO2与出生时身长和体重的减少有关。这种联系对于那些花更多时间呆在家里的女性来说更加明显。
Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children’s Health and Environment (INMA) mother and child cohort study. Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regression models controlled for potential confounders. We also performed sensitivity analyses for the subset of women who spent more time at home during pregnancy. Finally, we performed a combined analysis with meta-analysis techniques. Results: In the combined analysis, an increase of 10 µg/m3 in NO2 exposure during pregnancy was associated with a decrease in birth length of –0.9 mm [95% confidence interval (CI), –1.8 to –0.1 mm]. For the subset of women who spent ≥ 15 hr/day at home, the association was stronger (–0.16 mm; 95% CI, –0.27 to –0.04). For this same subset of women, a reduction of 22 g in birth weight was associated with each 10-µg/m3 increase in NO2 exposure in the second trimester (95% CI, –45.3 to 1.9). We observed no significant relationship between benzene levels and birth outcomes. Conclusions: NO2 exposure was associated with reductions in both length and weight at birth. This association was clearer for the subset of women who spent more time at home.
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影响因子：
2
作者：
Rigby, RA;Stasinopoulos, DM
通讯作者：
Stasinopoulos, DM
影响因子：
10.4
作者：
Mohorovic L
通讯作者：
Mohorovic L
影响因子：
13.6
作者：
Lacasaña, M;Esplugues, A;Ballester, F
通讯作者：
Ballester, F
影响因子：
4.5
作者：
Esposito, Emily R.;Horn, Kristin H.;Pisano, M. Michele
通讯作者：
Pisano, M. Michele
影响因子：
9.8
作者：
Iniguez, Carmen;Ballester, Ferran;Esplugues, Ana
通讯作者：
Esplugues, Ana