Body mass index and survival after cancer diagnosis: A pan-cancer cohort study of 114 430 patients with cancer.
Body mass index and survival after cancer diagnosis: A pan-cancer cohort study of 114 430 patients with cancer.
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DOI：
10.1016/j.xinn.2022.100344
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发表时间：
2022-11-08
期刊：
影响因子：
32.1
通讯作者：
Rodriguez, Alma
中科院分区：
文献类型：
--
作者：
Tu, Huakang;McQuade, Jennifer L.;Davies, Michael A.;Huang, Maosheng;Xie, Kunlin;Ye, Yuanqing;Chow, Wong-Ho;Rodriguez, Alma;Wu, Xifeng;Davies, Michael A.;Huang, Maosheng;Xie, Kunlin;Ye, Yuanqing;Rodriguez, Alma
鼓励癌症患者保持正常的身体质量指数（BMI）的建议很大程度上是根据患癌症风险的数据推断出来的。我们测试了癌症患者诊断期（诊断后1年内）BMI与全因死亡率之间的前瞻性关联。在7.2年的随访期间，114430名癌症患者中有42%（48340人）死亡。样条分析显示，与BMI为22.5的人相比，BMI低于22.5的人患24种癌症的全因死亡率增加。BMI高于22.5与全因死亡率降低相关，但观察到非线性关联；BMI为29.6 ~ 34.2时风险最低，BMI非常高时风险开始恢复至1以上。在24种癌症类型中的23种中观察到高BMI降低的死亡风险，并在试图消除潜在的选择偏差、吸烟和合共病的混淆以及保留因果关系后保持不变。与正常BMI（18.5-24.9）相比，超重BMI（25-29.9）和肥胖BMI（≥30）的风险比分别为0.85（95%可信区间[CI]， 0.83-0.87）和0.82(0.80-0.85)，并且在不同癌症类型和不同亚组之间的关联基本一致。肥胖的BMI指数与预期寿命增加有关，男性为6年，女性为3年。总之，虽然超重/肥胖的BMI会增加一般人群患癌症的风险，但超重/肥胖的诊断期BMI与癌症患者更长的生存期有关。超重或轻度肥胖与癌症患者更好的生存相关。对于超重或轻度肥胖的癌症患者，减肥可能是有害的
The recommendation encouraging patients with cancer to keep a normal body mass index (BMI) is largely extrapolated from data on risk of developing cancer. We tested the prospective association between peri-diagnostic (within 1 year post-diagnosis) BMI and all-cause mortality in patients with incident cancers. During 7.2 years of follow-up, 42% (48,340) of the 114 430 patients with cancer died. Spline analysis revealed that compared with a BMI of 22.5, a BMI lower than 22.5 was associated with increased risk of all-cause mortality across 24 cancer types. A BMI higher than 22.5 was associated with reduced all-cause mortality, while a non-linear association was observed; the lowest risk was found at a BMI of 29.6–34.2, and the risk started to return to and above unity at very high BMI values. The reduced mortality risk of high BMI was observed in 23 of 24 cancer types and maintained after attempts to remove potential selection bias, confounding by smoking and comorbidities, and reserve causality. Compared with a normal BMI of 18.5–24.9, the hazard ratios were 0.85 (95% confidence interval [CI], 0.83–0.87) for an overweight BMI (25–29.9) and 0.82 (0.80–0.85) for an obese BMI (≥30), and the associations were generally consistent across cancer types and various subgroups. Obese BMI was associated with increased life expectancy, up to 6 years among men and 3 years among women. In conclusion, while overweight/obese BMI increases the risk of developing cancer in the general population, overweight/obese peri-diagnostic BMI was associated with longer survival in cancer patients. Excess body weight increases the risk of developing cancer in general population Overweight or mild obesity was associated with better survival in cancer patients It may be harmful for overweight or mildly obese cancer patients to lose weight
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影响因子：
8.8
作者：
Demark-Wahnefried W;Rais-Bahrami S;Desmond RA;Gordetsky JB;Hunter GR;Yang ES;Azrad M;Frugé AD;Tsuruta Y;Norian LA;Segal R;Grizzle WE
通讯作者：
Grizzle WE
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
3.7
作者：
Jackson SE;Heinrich M;Beeken RJ;Wardle J
通讯作者：
Wardle J
影响因子：
8.4
作者：
Antoun, Sami;Bayar, Amine;Loriot, Yohann
通讯作者：
Loriot, Yohann
影响因子：
28.4
作者：
Caan, Bette J.;Feliciano, Elizabeth M. Cespedes;Chen, Wendy Y.
通讯作者：
Chen, Wendy Y.