Weight Loss and Mortality in Overweight and Obese Cancer Survivors: A Systematic Review.
Weight Loss and Mortality in Overweight and Obese Cancer Survivors: A Systematic Review.
复制标题
DOI：
10.1371/journal.pone.0169173
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wardle J
中科院分区：
文献类型：
--
作者：
Jackson SE;Heinrich M;Beeken RJ;Wardle J
过度肥胖是癌症生存率较低的风险因素，但减肥是否能降低风险还不确定。我们对超重或肥胖癌症幸存者的体重减轻和死亡率的文献进行了严格的审查。我们系统性地检索了PubMed和EMBASE中报告超重/肥胖伴肥胖相关癌症患者体重减轻与死亡率（癌症特异性或全因）相关性的文章。在可用的情况下，对来自非超重患者的相同研究的数据进行比较。纳入了5篇描述乳腺癌幸存者观察性研究的文章。四项研究报告了体重减轻与超重/肥胖幸存者死亡率之间的正相关性，其余研究未观察到显著相关性。非超重幸存者的结果相似。质量评估表明，研究之间存在高偏倚风险。目前缺乏观察证据表明减肥可以提高超重和肥胖癌症幸存者的生存率。然而，这些研究中存在偏差的可能性相当大，结果可能反映了与疾病相关而不是故意减肥的后果。需要更强的研究设计，纳入减肥的意向性措施，并扩展到其他癌症。
Excess adiposity is a risk factor for poorer cancer survival, but there is uncertainty over whether losing weight reduces the risk. We conducted a critical review of the literature examining weight loss and mortality in overweight or obese cancer survivors. We systematically searched PubMed and EMBASE for articles reporting associations between weight loss and mortality (cancer-specific or all-cause) in overweight/obese patients with obesity-related cancers. Where available, data from the same studies on non-overweight patients were compared. Five articles describing observational studies in breast cancer survivors were included. Four studies reported a positive association between weight loss and mortality in overweight/obese survivors, and the remaining study observed no significant association. Results were similar for non-overweight survivors. Quality assessment indicated high risk of bias across studies. There is currently a lack of observational evidence that weight loss improves survival for overweight and obese cancer survivors. However, the potential for bias in these studies is considerable and the results likely reflect the consequences of disease-related rather than intentional weight loss. There is a need for stronger study designs, incorporating measures of intentionality of weight loss, and extended to other cancers.
登录
查看更多内容
DOI：
10.1016/j.jada.2011.10.022
发表时间：
2012-04-01
影响因子：
4.8
作者：
Campbell, Kristin L.;Van Patten, Cheri L.;McKenzie, Donald C.
通讯作者：
McKenzie, Donald C.
影响因子：
6.2
作者：
Andrykowski, Michael A.;Donovan, Kristine A.;Laronga, Christine;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.
影响因子：
--
作者：
Andreyeva, Tatiana;Long, Michael W.;Grode, Gabrielle M.
通讯作者：
Grode, Gabrielle M.
DOI：
10.1097/ede.0b013e31824596a1
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bradshaw PT;Ibrahim JG;Stevens J;Cleveland R;Abrahamson PE;Satia JA;Teitelbaum SL;Neugut AI;Gammon MD
通讯作者：
Gammon MD
影响因子：
3.1
作者：
Anderson, Annie S.;Steele, Robert;Coyle, Joanne
通讯作者：
Coyle, Joanne