Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer.
Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer.
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DOI：
10.1038/bjc.2017.303
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发表时间：
2017-10-24
影响因子：
8.8
通讯作者：
Grizzle WE
中科院分区：
文献类型：
--
作者：
Demark-Wahnefried W;Rais-Bahrami S;Desmond RA;Gordetsky JB;Hunter GR;Yang ES;Azrad M;Frugé AD;Tsuruta Y;Norian LA;Segal R;Grizzle WE
肥胖与侵袭性前列腺癌有关。为了探讨体重减轻是否对肿瘤生物学和其他结果产生有利影响，我们在超重和肥胖的前列腺癌男性中进行了一项术前试验。这项单盲、双臂随机对照试验探讨了术前减肥干预（WLI）的结局，通过热量限制和增加体力活动（PA）促进每周体重减轻1.5 kg。40例临床确诊的超重/肥胖男性前列腺癌患者随机分配至WLI术前组或对照组;评价肿瘤和良性前列腺组织中体重、身体成分、生活质量、循环生物标志物、基因表达和免疫组织化学标志物的变化。研究周期平均为50天。平均值（s.d.）WLI与对照组的变化评分如下：体重：-4.7（3.1）千克vs −2.2千克（4.4）公斤（P=0.0508）;热量摄入：每天-500（636）kcal vs-159（600）kcal（P=0.0034）; PA：+0.9（3.1）vs +1.7（4.6）MET-小时/天（NS）;活力：+5.3（7.14）vs −1.8（8.1）（P=0.0491）;睾酮：+55.1（86.0）vs −48.3（203.7）ng dl−1（P=0.0418）;性激素结合球蛋白：+14.0（14.6）vs +1.8（7.6）nmol l−1（P=0.0023）;瘦素：-2.16（2.6）vs-0.03（3.75）（P=0.0355）。WLI组随访Ki 67显著高于对照组;中位数（四分位距）：5.0（2.5，10.0）vs 0.0（0.0，2.5）（P=0.0061），几个基因上调，例如CTSL、GSK 3B、MED 12和LAMC 2。有意减肥显示对循环生物标志物、肿瘤基因表达和增殖标志物的混合效应。在建议前列腺癌患者减肥之前，需要进行更多的研究，特别是快速减肥。
Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer. This single-blinded, two-arm randomised controlled trial explored outcomes of a presurgical weight loss intervention (WLI) that promoted ∼1 kg per week loss via caloric restriction and increased physical activity (PA). Forty overweight/obese men with clinically confirmed prostate cancer were randomised to the WLI presurgery or to a control arm; changes in weight, body composition, quality-of-life, circulating biomarkers, gene expression, and immunohistochemical markers in tumour and benign prostatic tissue were evaluated. The study period averaged 50 days. Mean (s.d.) change scores for the WLI vs control arms were as follows: weight: −4.7 (3.1) kg vs −2.2 (4.4) kg (P=0.0508); caloric intake: −500 (636) vs −159 (600) kcal per day (P=0.0034); PA: +0.9 (3.1) vs +1.7 (4.6) MET-hours per day (NS); vitality: +5.3 (7.l4) vs −1.8 (8.1) (P=0.0491); testosterone: +55.1 (86.0) vs −48.3 (203.7) ng dl−1 (P=0.0418); sex hormone-binding globulin: +14.0 (14.6) vs +1.8 (7.6) nmol l−1 (P=0.0023); and leptin: −2.16 (2.6) vs −0.03 (3.75) (P=0.0355). Follow-up Ki67 was significantly higher in WLI vs control arms; median (interquartile range): 5.0 (2.5,10.0) vs 0.0 (0.0,2.5) (P=0.0061) and several genes were upregulated, for example, CTSL, GSK3B, MED12, and LAMC2. Intentional weight loss shows mixed effects on circulating biomarkers, tumour gene expression, and proliferative markers. More study is needed before recommending weight loss, in particular rapid weight loss, among men with prostate cancer.
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DOI：
10.1158/1055-9965.epi-08-0008
发表时间：
2008-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Demark-Wahnefried W;Polascik TJ;George SL;Switzer BR;Madden JF;Ruffin MT 4th;Snyder DC;Owzar K;Hars V;Albala DM;Walther PJ;Robertson CN;Moul JW;Dunn BK;Brenner D;Minasian L;Stella P;Vollmer RT
通讯作者：
Vollmer RT
影响因子：
5
作者：
BLAIR, SN;HASKELL, WL;WOOD, PD
通讯作者：
WOOD, PD
影响因子：
3.7
作者：
Steins Bisschop CN;Courneya KS;Velthuis MJ;Monninkhof EM;Jones LW;Friedenreich C;van der Wall E;Peeters PH;May AM
通讯作者：
May AM
影响因子：
3.8
作者：
Demark-Wahnefried W;Nix JW;Hunter GR;Rais-Bahrami S;Desmond RA;Chacko B;Morrow CD;Azrad M;Frugé AD;Tsuruta Y;Ptacek T;Tully SA;Segal R;Grizzle WE
通讯作者：
Grizzle WE
影响因子：
3.8
作者：
Fabian, Carol J.;Kimler, Bruce F.;Donnelly, Joseph E.;Sullivan, Debra K.;Klemp, Jennifer R.;Petroff, Brian K.;Phillips, Teresa A.;Metheny, Trina;Aversman, Sonya;Yeh, Hung-wen;Zalles, Carola M.;Mills, Gordon B.;Hursting, Stephen D.
通讯作者：
Hursting, Stephen D.