Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
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DOI:
10.1002/anie.201205775
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发表时间:
2013-01-02
影响因子:
16.6
通讯作者:
Dervan, Peter B.
中科院分区:
文献类型:
--
作者:
Chenoweth, David M.;Meier, Jordan L.;Dervan, Peter B.
Groove specificity. Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. Here we demonstrate that polyamides do not similarly bind duplex RNA, and offer a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor groove binding ligands.
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