Immunohistochemical Evaluation of FGD3 Expression: A New Strong Prognostic Factor in Invasive Breast Cancer.
Immunohistochemical Evaluation of FGD3 Expression: A New Strong Prognostic Factor in Invasive Breast Cancer.
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FGD 3表达的免疫组化评价：浸润性乳腺癌中一个新的强预后因素。
DOI：
10.3390/cancers13153824
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发表时间：
2021-07-29
期刊：
影响因子：
5.2
通讯作者：
Bianchi S
中科院分区：
文献类型：
--
作者：
Susini T;Saccardin G;Renda I;Giani M;Tartarotti E;Nori J;Vanzi E;Pasqualini E;Bianchi S
乳腺癌是女性发病率最高的恶性肿瘤，也是女性肿瘤死亡的主要原因。这种疾病治疗的最新进展归功于个体化治疗能力的不断增强，即所谓的“精准医学”时代。该方法基于对肿瘤分子和遗传特征的了解。因此，我们不断寻找新的预后因素，使我们能够根据患者的个体风险更好地对其进行分层。最有希望的似乎是 FGD3 基因表达，它已被证明在乳腺癌中具有预后作用：我们研究的目的是通过免疫组织化学分析 FGD3 表达的预后价值，并将其与传统因素进行比较。免疫组织化学简单且便宜；通过其使用提供比经典预后因素更强的预后因素可能会极大地有助于这种疾病的实际管理。在乳腺癌的新预后因素中，最有希望的一个似乎是 FGD3（Facio-Genital Dysplasia 3）基因，该基因的表达通过抑制细胞迁移来改善预后。本研究的目的是通过免疫组织化学评估 FGD3 基因的表达，评估 FGD3 在我们单位治疗的 401 名女性浸润性乳腺癌中的预后作用。 FGD3 高表达的患者表现出明显更好的无病生存 (DFS) (p < 0.001) 和总生存 (OS) (p < 0.001)。 FGD3表达的预后价值强于组织学分化分级、Ki-67指数和分子亚型等经典病理参数。通过多变量 Cox 分析，FGD3 表达被证实是重要且独立的预后因素，在 DFS 方面排名第二，仅次于诊断年龄（≤ 40 岁）（p = 0.003），在 AJCC 分期之后排名第二强的 OS 预测因子（p < 0.001）。我们的数据表明，将 FGD3 评估纳入乳腺癌患者的常规检查可能会导致更准确的个体风险分层。通过简单且廉价的技术（例如免疫组织化学）评估 FGD3 表达的可能性可能会增强其在临床实践中的使用传播。
Breast cancer is the most incident malignancy and the leading cause of oncological death among women. The recent advances in the treatment of this disease are due to the increasing ability to individualize therapy, in the so called “precision medicine” era. This approach is based on the knowledge of molecular and genetic features of the tumor. Therefore, there is a continuous search for new prognostic factors that may allow us to better stratify patients according to their individual risk. The most promising one seems to be the FGD3 gene expression, which has been shown to be prognostic in breast cancer: the aim of our study was to analyze the prognostic value of FGD3 expression by immunohistochemistry and to compare it with traditional factors. Immunohistochemistry is easy and cheap; to provide by its use a prognostic factor stronger than classical ones may greatly aid in the practical management of this disease. Among new prognostic factors for breast cancer, the most promising one seems to be FGD3 (Facio-Genital Dysplasia 3) gene, whose expression improves outcome by inhibiting cell migration. The aim of the study was to evaluate the prognostic role of FGD3 in invasive breast cancer in a series of 401 women, treated at our unit, by evaluating the expression of this gene by immunohistochemistry. Patients with high FGD3 expression showed a significantly better disease-free survival (DFS) (p < 0.001) and overall survival (OS) (p < 0.001). The prognostic value of FGD3 expression was stronger than that of classical pathologic parameters such as histological grade of differentiation, Ki-67 index and molecular subtype. By multivariate Cox analysis, FGD3 expression was confirmed as significant and independent prognostic factor, ranking second after age at diagnosis (≤40 years) for DFS (p = 0.003) and the second strongest predictor of OS, after AJCC Stage (p < 0.001). Our data suggest that inclusion of FGD3 evaluation in the routine workup of breast cancer patients may result in a more accurate stratification of the individual risk. The possibility to assess FGD3 expression by a simple and cheap technique such as immunohistochemistry may enhance the spread of its use in the clinical practice.
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影响因子：
3.8
作者：
Kataoka, Akemi;Iwamoto, Takayuki;Tokunaga, Eriko;Tomotaki, Ai;Kumamaru, Hiraku;Miyata, Hiroaki;Niikura, Naoki;Kawai, Masaaki;Anan, Keisei;Hayashi, Naoki;Masuda, Shinobu;Tsugawa, Koichiro;Aogi, Kenjiro;Ishida, Takanori;Masuoka, Hideji;Iijima, Kotaro;Kinoshita, Takayuki;Nakamura, Seigo;Tokuda, Yutaka
通讯作者：
Tokuda, Yutaka
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
DOI：
10.1093/jnci/djy088
发表时间：
2018-08-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Sauerbrei W;Taube SE;McShane LM;Cavenagh MM;Altman DG
通讯作者：
Altman DG
影响因子：
16.9
作者：
Agarwal, Shailesh;Pappas, Lisa;Agarwal, Jayant
通讯作者：
Agarwal, Jayant
DOI：
10.4103/0971-5851.180136
发表时间：
2016-04-01
影响因子：
0.2
作者：
Madani, Seyed-Hamid;Payandeh, Mehrdad;Sadeghi, Edris
通讯作者：
Sadeghi, Edris