Microfluidic approaches to malaria pathogenesis.
Microfluidic approaches to malaria pathogenesis.
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DOI：
10.1111/j.1462-5822.2008.01216.x
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发表时间：
2008-10
影响因子：
3.4
通讯作者：
Rathod PK
中科院分区：
文献类型：
--
作者：
Antia M;Herricks T;Rathod PK
疟疾是世界上与贫困有关的主要人类传染病。每年有超过10亿人受到威胁，数百万人死于疟疾。疾病的本质，特别是致命疾病，一直是许多研究的主题。目前的共识是，寄生虫诱导的红细胞粘附会导致受影响器官的毛细血管阻塞和炎症反应。受感染红细胞的变形能力降低也可能导致疾病。目前尚不清楚的是，为什么寄生虫负担严重的人在疾病结果上表现出很大的差异。允许详细描述个体患者中受感染的红细胞的细胞粘附特性并且允许完整描述该患者中红细胞群体的流动能力的技术将是非常有用的。在这里，我们回顾了最近引进的微流体技术来研究疟疾发病机制，包括制造过程。这些设备便宜、通用、便携，并且需要非常小的患者样本。随着微流控技术在研究实验室和现场的广泛应用，我们最终期望微流控技术在疟疾诊断和预后中发挥重要作用。
Malaria is a major poverty-related human infectious disease of the world. Over a billion individuals are under threat and several million die from malaria every year. The nature of disease, especially fatal disease, has been the subject of many studies. The consensus is that parasite-induced cytoadherance of red blood cells precipitates capillary blockage and inflammatory responses in affected organs. Reduced deformability of infected erythrocytes may also contribute to disease. What is not very clear is why people with significant parasite burdens display large variations in disease outcomes. Technologies which allow a detailed description of the cytoadherance properties of infected erythrocytes in individual patients, and which allow a complete description of the flow capabilities of red blood cell populations in that patient, would be very useful. Here we review the recent introduction of microfluidic technology to study malaria pathogenesis, including the fabrication processes. The devices are cheap, versatile, portable and require very small patient samples. With greater use in research laboratories and field sites, we eventually expect microfluidic methods to play important roles in malaria diagnosis, as well as prognosis.
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影响因子：
56.9
作者：
Fried, M;Duffy, PE
通讯作者：
Duffy, PE
影响因子：
64.8
作者：
BERENDT, AR;SIMMONS, DL;MARSH, K
通讯作者：
MARSH, K
影响因子：
56.9
作者：
SCHNITZER, B;SODEMAN, T;MEAD, ML
通讯作者：
MEAD, ML
DOI：
10.1073/pnas.93.8.3497
发表时间：
1996-04-16
影响因子：
11.1
作者：
Baruch, DI;Gormley, JA;Pasloske, BL
通讯作者：
Pasloske, BL
影响因子：
2.7
作者：
Dondorp, AM;Pongponratn, E;White, NJ
通讯作者：
White, NJ