Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.
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DOI：
10.1001/archpediatrics.2011.565
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发表时间：
2011-12
影响因子：
--
通讯作者：
Blumberg, Hilary P.
中科院分区：
文献类型：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
研究无精神病诊断的青少年自我报告的儿童期虐待与大脑灰质的关系。儿童期虐待（通过儿童期创伤自我报告问卷测量身体，情感和性虐待，身体和情感忽视）和区域灰质之间的关联进行了研究。大学医院。42名青少年没有精神疾病。儿童期创伤问卷评分和区域灰质体积之间的相关性在基于体素的结构磁共振扫描分析中进行了评估。探讨了灰质体积与儿童期虐待亚型和性别之间的关系。儿童期创伤问卷总分与前额叶皮层、纹状体、杏仁核、感觉联合皮层和小脑的灰质体积呈负相关（p<0.005）。身体虐待，身体忽视和情感忽视与吻侧前额叶减少。此外，背外侧和眶额皮质、杏仁核和腹侧纹状体的减少与身体虐待有关，小脑与身体忽视有关，背外侧、眶额和膝下前额叶皮质、纹状体、杏仁核、海马和小脑与情感忽视有关。这些后者的情绪调节区域也与女性的童年创伤问卷分数，而尾状核减少，这可能与冲动失控，被认为是在男性。儿童期虐待与青少年皮质纹状体边缘灰质减少有关。这些研究结果表明，即使报告儿童期虐待暴露的青少年没有出现符合精神疾病完全标准的症状，他们也可能有皮质纹状体边缘系统的变化，使他们面临行为困难的风险。脆弱性可能会受到性别和虐待亚型的影响。
To study the relationship between self-reported childhood maltreatment and cerebral gray matter in adolescents without psychiatric diagnoses. Associations between childhood maltreatment (measured by a childhood trauma self-report questionnaire for physical, emotional and sexual abuse, and physical and emotional neglect) and regional gray matter were examined. University hospital. 42 adolescents without psychiatric disorders. Correlations between childhood trauma questionnaire scores and regional gray matter volume were assessed in voxel-based analyses of structural magnetic resonance scans. Relationships between gray matter volume and childhood maltreatment subtypes and gender where explored. Total childhood trauma questionnaire scores correlated negatively (p<0.005) with gray matter volumes in prefrontal cortex, striatum, amygdala, sensory association cortices and cerebellum. Physical abuse, physical neglect and emotional neglect were associated with rostral prefrontal reductions. Additionally, decreases in dorsolateral and orbitofrontal cortices, insula, and ventral striatum were associated with physical abuse, in cerebellum with physical neglect, and in dorsolateral, orbitofrontal and subgenual prefrontal cortices, striatum, amygdala, hippocampus and cerebellum with emotional neglect. These latter emotion regulation regions were also associated with childhood trauma questionnaire scores in females, while caudate reductions, which may relate to impulse dyscontrol, were seen in males. Childhood maltreatment was associated with corticostriatal-limbic gray matter reductions in adolescents. These findings suggest that even if adolescents reporting childhood maltreatment exposure do not present with symptoms that meet full criteria for psychiatric disorders, they may have corticostriatal-limbic changes that place them at risk for behavioral difficulties. Vulnerabilities may be moderated by gender and maltreatment subtype.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
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作者：
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通讯作者：
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DOI：
10.1196/annals.1308.017
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Arnsten, AFT;Shansky, RM
通讯作者：
Shansky, RM
DOI：
10.1017/s1355617709990464
发表时间：
2009-11
影响因子：
2.6
作者：
De Bellis, Michael D.;Hooper, Stephen R.;Spratt, Eve G.;Woolley, Donald P.
通讯作者：
Woolley, Donald P.
DOI：
10.1073/pnas.0935845100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Carr, L;Iacoboni, M;Lenzi, GL
通讯作者：
Lenzi, GL