Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex.
Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex.
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DOI：
10.1093/gerona/glab297
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发表时间：
2022-01-07
期刊：
影响因子：
--
通讯作者：
Howlett SE
中科院分区：
文献类型：
--
作者：
Bisset ES;Heinze-Milne S;Grandy SA;Howlett SE
Aerobic exercise is a promising intervention to attenuate frailty, but preclinical studies have used only male animals. We investigated the impact of voluntary aerobic exercise on frailty, biological age (FRailty Inferred Geriatric Health Timeline [FRIGHT] clock), predicted life expectancy (Analysis of FRAIlty and Death [AFRAID] clock), and mortality in both sexes and determined whether exercise was associated with changes in inflammation. Older (21–23 months) male (n = 12) and female (n = 22) C57Bl/6 mice matched for baseline frailty scores were randomized into exercise (running wheel) and sedentary (no wheel) groups. Frailty index scores were measured biweekly (13 weeks), and 23 serum cytokines were measured at midpoint and end point. Exercise levels varied between mice but not between the sexes. Exercise had no effect on mortality, but it attenuated the development of frailty in both sexes (female = 0.32 ± 0.04 vs 0.21 ± 0.01; p = .005; male = 0.30 ± 0.02 vs 0.22 ± 0.02; p = .042) and reduced frailty in older females after 10 weeks. FRIGHT scores were unaffected by exercise but increased with time in sedentary males indicating increased biological age. Exercise prevented the age-associated decline in AFRAID scores in older females such that exercised females had a longer life expectancy. We investigated whether aerobic exercise was associated with changes in systemic inflammation. Cytokine levels were not affected by exercise in males, but levels of pro-inflammatory cytokines were positively correlated with the frequency of exercise in females. Despite increases in systemic inflammation, exercise reduced frailty and increased life span in older females. Thus, voluntary aerobic exercise, even late in life, has beneficial effects on health in both sexes but may be especially helpful in older females.
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DOI：
10.1093/gerona/gly117
发表时间：
2019-03-01
影响因子：
5.1
作者：
Kane, Alice E.;Keller, Kaitlyn M.;Howlett, Susan E.
通讯作者：
Howlett, Susan E.
影响因子：
5.2
作者：
Baumann, Cory W.;Kwak, Dongmin;Thompson, LaDora, V
通讯作者：
Thompson, LaDora, V
影响因子：
5.3
作者：
Seldeen, Kenneth Ladd;Redae, Yonas Z.;Troen, Bruce Robert
通讯作者：
Troen, Bruce Robert
影响因子：
3.4
作者：
Bray, Nick W.;Smart, Rowan R.;Jones, Gareth R.
通讯作者：
Jones, Gareth R.
影响因子：
4.1
作者：
Petrella M;Aprahamian I;Mamoni RL;de Vasconcellos Romanini CF;Lima NA;de Cássio Robello E;da Costa DL;An VN;Aguirre BN;Galdeano JR;Fernandes IC;Soleman Hernandez SS;Cesari M;Morley JE;Izquierdo M;Oude Voshaar RC
通讯作者：
Oude Voshaar RC