The effect of a multicomponent exercise protocol (VIVIFRAIL©) on inflammatory profile and physical performance of older adults with different frailty status: study protocol for a randomized controlled trial.
The effect of a multicomponent exercise protocol (VIVIFRAIL©) on inflammatory profile and physical performance of older adults with different frailty status: study protocol for a randomized controlled trial.
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DOI：
10.1186/s12877-021-02030-2
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发表时间：
2021-01-29
期刊：
影响因子：
4.1
通讯作者：
Oude Voshaar RC
中科院分区：
文献类型：
--
作者：
Petrella M;Aprahamian I;Mamoni RL;de Vasconcellos Romanini CF;Lima NA;de Cássio Robello E;da Costa DL;An VN;Aguirre BN;Galdeano JR;Fernandes IC;Soleman Hernandez SS;Cesari M;Morley JE;Izquierdo M;Oude Voshaar RC
To investigate whether an exercise intervention using the VIVIFRAIL© protocol has benefits for inflammatory and functional parameters in different frailty status. This is a randomized clinical trial in an outpatient geriatrics clinic including older adults ≥60 years. For each frailty state (frail, pre-frail and robust), forty-four volunteers will be randomly allocated to the control group (n = 22) and the intervention group (n = 22) for 12 weeks. In the control group, participants will have meetings of health education while those in the intervention group will be part of a multicomponent exercise program (VIVIFRAIL©) performed five times a week (two times supervised and 3 times of home-based exercises). The primary outcome is a change in the inflammatory profile (a reduction in inflammatory interleukins [IL-6, TNF- α, IL1beta, IL-17, IL-22, CXCL-8, and IL-27] or an increase in anti-inflammatory mediators [IL-10, IL1RA, IL-4]). Secondary outcomes are change in physical performance using the Short Physical Performance Battery, handgrip strength, fatigue, gait speed, dual-task gait speed, depressive symptoms, FRAIL-BR and SARC-F scores, and quality of life at the 12-week period of intervention and after 3 months of follow-up. We expect a reduction in inflammatory interleukins or an increase in anti-inflammatory mediators in those who performed the VIVIFRAIL© protocol. The results of the study will imply in a better knowledge about the effect of a low-cost intervention that could be easily replicated in outpatient care for the prevention and treatment of frailty, especially regarding the inflammatory and anti-inflammatory pathways involved in its pathophysiology. Brazilian Registry of Clinical Trials (RBR-9n5jbw; 01/24/2020). Registred January 2020. http://www.ensaiosclinicos.gov.br/rg/RBR-9n5jbw/.
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影响因子：
168.9
作者：
Moher, D;Schulz, KF;Altman, DG
通讯作者：
Altman, DG
影响因子：
5.8
作者：
Dent, E.;Morley, J. E.;Vellas, B.
通讯作者：
Vellas, B.
影响因子：
4
作者：
Hecksteden A;Faude O;Meyer T;Donath L
通讯作者：
Donath L
DOI：
10.1111/j.1532-5415.2012.04054.x
发表时间：
2012-08-01
影响因子：
6.3
作者：
Collard, Rose M.;Boter, Han;Voshaar, Richard C. Oude
通讯作者：
Voshaar, Richard C. Oude
影响因子：
4
作者：
McMahon, Gerard;Morse, Christopher, I;Onambele, Gladys L.
通讯作者：
Onambele, Gladys L.