Spatial characterization of interictal high frequency oscillations in epileptic neocortex.
Spatial characterization of interictal high frequency oscillations in epileptic neocortex.
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癫痫新皮质发作间期高频振荡的空间特征。
DOI：
10.1093/brain/awp222
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Emerson RG
中科院分区：
文献类型：
--
作者：
Schevon CA;Trevelyan AJ;Schroeder CE;Goodman RR;McKhann G Jr;Emerson RG
发作间期高频振荡(HFO)，特别是频率成分大于200赫兹的高频振荡，已被认为是癫痫皮质以及癫痫发作发生的重要生物标志物。我们使用一个密集的4×4mm2二维微电极阵列植入4例癫痫手术患者的新皮质，研究了HFO的空间范围、分类和分布。大多数(97%)检测到的振荡包括快速波动，并且集中在相对较少的记录点。虽然大多数∼仅限于单通道，但10%的HFO发生在更大的空间尺度上，在多个通道同时但在形态上不同的检测。这些大规模事件中80%与发作间期癫痫样放电有关。我们认为，临床深度电极检测到的高频振荡的底物是大范围的高频振荡，而不是更频繁的高焦点事件。这一特征在三名患者中表现突出，但仅在致痫皮质外记录的一名患者中罕见。此外，我们发现HFO通常与广泛的发作间期癫痫样放电有关，但与局部产生的“微放电”无关。我们的观察提出了这样一种可能性，即快速涟漪不是癫痫样活动的始发者，而可能是继发性局部反应的标志。
Interictal high frequency oscillations (HFOs), in particular those with frequency components in excess of 200 Hz, have been proposed as important biomarkers of epileptic cortex as well as the genesis of seizures. We investigated the spatial extent, classification and distribution of HFOs using a dense 4 × 4 mm2 two dimensional microelectrode array implanted in the neocortex of four patients undergoing epilepsy surgery. The majority (97%) of oscillations detected included fast ripples and were concentrated in relatively few recording sites. While most HFOs were limited to single channels, ∼10% occurred on a larger spatial scale with simultaneous but morphologically distinct detections in multiple channels. Eighty per cent of these large-scale events were associated with interictal epileptiform discharges. We propose that large-scale HFOs, rather than the more frequent highly focal events, are the substrates of the HFOs detected by clinical depth electrodes. This feature was prominent in three patients but rarely seen in only one patient recorded outside epileptogenic cortex. Additionally, we found that HFOs were commonly associated with widespread interictal epileptiform discharges but not with locally generated ‘microdischarges’. Our observations raise the possibility that, rather than being initiators of epileptiform activity, fast ripples may be markers of a secondary local response.
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